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Isoforms Recommended:	EAAT1

Results for "

EAAT1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ASCT (3) Bcl-2 Family (1) Caspase (1) EAAT (14) iGluR (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (12)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107521

TFB-TBOA 3 Publications Verification CF3-Bza-TBOA	EAAT	Neurological Disease
TFB-TBOA (CF3-Bza-TBOA) is a potent glutamate transporter blocker that potently suppresses the activity of glial transporters. TFB-TBOA shows IC₅₀ values of 22, 17, and 300 nM for glutamate transporters EAAT1, EAAT2, and EAAT3 respectively in an uptake assay using cells transiently expressing EAATs .

HY-10914

UCPH-101 1 Publications Verification	EAAT	Neurological Disease
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC₅₀ of 0.66 μM.

HY-100801

L-threo-3-Hydroxyaspartic acid	EAAT	Neurological Disease
L-threo-3-Hydroxyaspartic acid is a potent *EAAT* inhibitor with K_is of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines ^[1].

HY-107522

DL-TBOA 1 Publications Verification	EAAT	Neurological Disease
DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC₅₀s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), *EAAT2* and *EAAT3, respectively. DL-TBOA inhibits the uptake of [ ¹⁴C]glutamate in COS-1 cells expressing the human EAAT1* and *EAAT2* with K_i valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks *EAAT4* and *EAAT5* in a competitive manner with K_i values of 4.4 μM and 3.2 μM, respectively ^[1] .

HY-146241B

SN40 hydrochloride	EAAT ASCT	Others
SN40 hydrochloride is a potent amino acid transport (AAT) inhibitor with K_is of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 hydrochloride can be used for researching anticancer ^[1].

HY-146241

SN40	EAAT ASCT	Cancer
SN40 is a potent amino acid transport (AAT) inhibitor with K_is of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 can be used for researching anticancer ^[1].

HY-146242

SN05	EAAT ASCT	Cancer
SN05 is a potent amino acid transport (AAT) inhibitor with K_i values of 2.77 μM, 0.73 μM, 0.87 μM, 3.7 μM, 7.25 μM, 7.23 μM and 2.22 μM for *hASCT1, rASCT2, hASCT2, EAAT1, EAAT2, EAAC1* and *EAAT5*, respectively. SN05 can be used in the study of cancer ^[1].

HY-118858

UCPH-102	EAAT	Neurological Disease Cancer
UCPH-102 is a highly selective *EAAT1* inhibitor with an IC₅₀ of 0.43 µM. UCPH-102 exhibits a specific anti-proliferative effect on T-ALL cells. UCPH-102 also shows good blood-brain permeability, which can be used in studies of amyotrophic lateral sclerosis, Alzheimer’s disease, chronic pain and obsessive compulsive disorder ^[1] .

HY-107522B

DL-TBOA ammonium	EAAT	Neurological Disease
DL-TBOA ammonium is a potent non-transportable inhibitor of excitatory amino acid transporters with IC₅₀s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), *EAAT2* and *EAAT3, respectively. DL-TBOA ammonium inhibits the uptake of [ ¹⁴C]glutamate in COS-1 cells expressing the human EAAT1* and *EAAT2* with K_i valuesof 42 μM and 5.7 μM, respectively. DL-TBOA ammonium blocks *EAAT4* and *EAAT5* in a competitive manner with K_i values of 4.4 μM and 3.2 μM, respectively ^[1] .

HY-130125

*SLC1A1/EAAT3-IN-1*	EAAT	Neurological Disease
SLC1A1/EAAT3-IN-1 (Compound 3e) is a selective *EAAT3* inhibitor with an IC₅₀ of 7.2  μM for hEAAT3 over EAAT1,2,4 (IC₅₀: ∼ 250 μM). SLC1A1/EAAT3-IN-1 can be used for psychiatric disorders such as obsessive compulsive disorder and schizophrenia research ^[1].

HY-107661

Arundic Acid 2 Publications Verification ONO-2506; (R)-2-Propyloctanoic acid	Others	Neurological Disease
Arundic acid (ONO-2506) is an astrocyte-modulating agent, which delays the expansion of cerebral infarcts by modulating the activation of astrocytes through inhibition of S-100β synthesis. Arundic acid also increases the expression level of *EAAT1* by activating the Akt, ERK, and NF-κB signaling pathways, which has the potential to eliminate excess glutamate and inhibit excitotoxic brain damage or death. Arundic acid has the potential for stroke and Alzheimer’s disease research ^[1] .

HY-101310

SYM 2081	iGluR EAAT Bcl-2 Family Caspase	Cardiovascular Disease Neurological Disease Inflammation/Immunology
SYM 2081 is a kainate receptor agonist. SYM 2081 is a substrate of *EAAT1* (K_m of 54 μM). SYM 2081 inhibits *EAAT2*-mediated glutamate transport (K_b is 3.4 μM in Xenopus oocytes), modulates Apoptotic signaling pathways (increases Bcl-2 and decreases Bax/caspase-3 expression). SYM 2081 exhibits neuroprotective activity. SYM 2081 can be used in the study of hypoxic-ischemic brain damage and inflammatory or neuropathic pain ^[1] .

HY-RS26023

Slc1a3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Slc1a3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Slc1a3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Slc1a3 Rat Pre-designed siRNA Set A Slc1a3 Rat Pre-designed siRNA Set A

HY-RS13054

SLC1A3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SLC1A3 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC1A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLC1A3 Human Pre-designed siRNA Set A SLC1A3 Human Pre-designed siRNA Set A

HY-107523

WAY-213613 3 Publications Verification	EAAT	Neurological Disease
WAY-213613 is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC₅₀ value of 85 nM. WAY-213613 can be used for the research of central nervous system ^[1]

HY-107523A

WAY-213613 hydrochloride 3 Publications Verification	EAAT	Neurological Disease
WAY-213613 (hydrochloride) is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC₅₀ value of 85 nM. WAY-213613 can be used for the research of central nervous system ^[1].

HY-100838

cis-α-(Carboxycyclopropyl)glycine L-CCG III	EAAT	Neurological Disease
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC₅₀: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na ⁺-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes ^[1] .

HY-RS19528

Slc1a3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Slc1a3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Slc1a3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Slc1a3 Mouse Pre-designed siRNA Set A Slc1a3 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-100838

cis-α-(Carboxycyclopropyl)glycine L-CCG III	EAAT	Neurological Disease
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC₅₀: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na ⁺-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes ^[1] .

L-threo-3-Hydroxyaspartic acid	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	EAAT
L-threo-3-Hydroxyaspartic acid is a potent *EAAT* inhibitor with K_is of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines ^[1].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82734

	EAAT1 Antibody (YA2479) SLC1A3; EAAT1; GLAST; GLAST1; Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3	WB, IHC-P	Human, Mouse, Rat
	EAAT1 Antibody (YA2479) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EAAT1.

HY-P86606

	EAAT1 Antibody (YA6298) SLC1A3; EAAT1; GLAST; GLAST1; Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	EAAT1 Antibody (YA6298) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EAAT1.

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