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Pathways Recommended:	Vitamin D Related/Nuclear Receptor

Results for "

E-3174 d<sub>4</sub>

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin Receptor (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Endocrinology (1)

Targets Recommended: P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12765S

Losartan-d4 (carboxylic acid) E-3174 d<sub>4sub>; EXP-3174 d<sub>4sub>	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan-d₄ carboxylic acid (E-3174-d₄) is the deuterium labeled Losartan Carboxylic Acid (HY-12765). Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K_i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.

Cat. No.	Product Name	Chemical Structure

HY-12765S

Losartan-d4 (carboxylic acid)
Losartan-d₄ carboxylic acid (E-3174-d₄) is the deuterium labeled Losartan Carboxylic Acid (HY-12765). Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K_i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.

Losartan-d4 (carboxylic acid)

Losartan-d₄ carboxylic acid (E-3174-d₄) is the deuterium labeled Losartan Carboxylic Acid (HY-12765). Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K_i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.

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E-3174 d<sub>4</sub>

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