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Results for "

Dihydrofolic acid

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

2

Natural
Products

2

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-137129
    10-Formyl-7,8-dihydrofolic acid

    		Endogenous Metabolite Metabolic Disease
    10-Formyl-7,8-dihydrofolic acid is a substrate for mammalian aminoimidazolecarboxamide ribotide transformylase (EC 2.1.2.3). 10-Formyl-7,8-dihydrofolic acid also is a metabolite of 10-HCO-H4folate .
    10-Formyl-7,8-dihydrofolic acid
  • HY-139743
    Aditoprime

    Aditoprim

    		 Antifolate Bacterial Infection
    Aditoprime (Aditoprim) is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR, respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics .
    Aditoprime
  • HY-B0512S
    Sulfamerazine-d4

    		Isotope-Labeled Compounds Bacterial Infection
    Sulfamerazine-d4 is a deuterium labeled Sulfamerazine. Sulfamerazine, a sulfonamide antibacterial, inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes .
    Sulfamerazine-d4
  • HY-N7123
    Sulfacetamide
    3 Publications Verification

    Sulphacetamide

    		 Antibiotic Bacterial Fungal Infection Inflammation/Immunology
    Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic. Sulfacetamide has antifungal and antibacterial activities. Sulfacetamide is employed as a topical formulation in various ophthalmic, dermatological, and hair solutions against bacterial infections, acne and scalp conditions. Sulfacetamide targets bacterial folic acid synthesis and is effective against various gram-positive and gram-negative bacteria. Sulfacetamide inhibits the synthesis of both dihydro-folic acid and para-aminobenzoic acid. Sulfacetamide can be used for the study of ocular infections .
    Sulfacetamide
  • HY-N7123R
    Sulfacetamide (Standard)

    Sulphacetamide (Standard)

    		 Reference Standards Antibiotic Bacterial Fungal Infection Inflammation/Immunology
    Sulfacetamide (Standard) (Sulphacetamide (Standard)) is the analytical standard of Sulfacetamide (HY-N7123). This product is intended for research and analytical applications. Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic. Sulfacetamide has antifungal and antibacterial activities. Sulfacetamide is employed as a topical formulation in various ophthalmic, dermatological, and hair solutions against bacterial infections, acne and scalp conditions. Sulfacetamide targets bacterial folic acid synthesis and is effective against various gram-positive and gram-negative bacteria. Sulfacetamide inhibits the synthesis of both dihydro-folic acid and para-aminobenzoic acid. Sulfacetamide can be used for the study of ocular infections .
    Sulfacetamide (Standard)
  • HY-139743R
    Aditoprime (Standard)

    Aditoprim (Standard)

    		 Reference Standards Antifolate Bacterial Infection
    Aditoprime (Standard) is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR, respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics .
    Aditoprime (Standard)
  • HY-177337
    N-Didesmethyladitoprim

    N-Didesmethyl-ADP

    		 Drug Metabolite Antifolate Bacterial Infection
    N-Didesmethyladitoprim is a metabolite of Aditoprime (HY-139743). Aditoprime is a selective bacterial dihydrofolate reductase (DHFR) inhibitor with IC50s of 47 and 520 nM for E.coli and L.casei DHFR , respectively. Aditoprime inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime has a broad-spectrum antibacterial activity and excellent pharmacokinetics .
    N-Didesmethyladitoprim
  • HY-121702
    Dihydrohomofolic acid

    		Drug Derivative Cancer
    Dihydrohomofolic acid, an analog of dihydrofolic acid (H2F), might be effective against tumor in which resistance to methotrexate (MTX) is associated with high leveIs of H2F-reductase .
    Dihydrohomofolic acid
  • HY-B0512S1
    Sulfamerazine-13C6

    RP2632-13C6

    		 Isotope-Labeled Compounds Bacterial Antibiotic Infection
    Sulfamerazine- 13C6 (RP2632- 13C6) is 13C labeled Sulfamerazine (HY-B0512). Sulfamerazine (RP-2632) is a sulfonamide antibacterial. Sulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes.
    Sulfamerazine-13C6
  • HY-B0337B
    Sulfadimethoxine 1000 µg/mL in methanol

    Sulphadimethoxine 1000 µg/mL in methanol

    		 Antibiotic Infection
    Sulfadimethoxine 1000 μg/mL in methanol (Sulphadimethoxine 1000 μg/mL in methanol) is a sulfonamide antibiotic that inhibits the enzyme dihydropteroate synthase, thereby blocking dihydrofolic acid synthesis and disrupting folic acid production in prokaryotic organisms. Its antimicrobial activity extends to both Gram-positive and Gram-negative bacteria, as well as Chlamydia. Resistance to this compound may arise through alterations in dihydropteroate synthase or the activation of alternative pathways for folic acid synthesis.
    Sulfadimethoxine 1000 µg/mL in methanol

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