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Deoxycytidine Kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (8) Drug Metabolite (1) Endogenous Metabolite (2) Reference Standards (1)
By Research Areas:	Cancer (8) Metabolic Disease (2)
Oligonucleotides:	Nucleosides and their Analogs (1) C (1)

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

DI-87 TRE-515	DNA/RNA Synthesis	Cancer
DI-87 is an orally active and selective deoxycytidine kinase (dCK) inhibitor with an EC₅₀ of 10.2 nM. DI-87 has antitumor activity and is used in combination therapy against tumors expressing dCK .

DI-82	DNA/RNA Synthesis	Cancer
DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC₅₀ ^app of 27.8 nM and K_i ^app of 9.2 nM. DI-82 has antitumor activity .

2'-Deoxycytidine-5'-monophosphate 1 Publications Verification 5'-dCMP; Deoxy-CMP; 2'-Deoxycytidine-5'-monophosphoric acid	Endogenous Metabolite	Metabolic Disease
2'-Deoxycytidine-5'-monophosphate (2'-Deoxycytidine-5'-monophosphoric acid) is an endogenous metabolite. 2'-Deoxycytidine-5'-monophosphate is a deoxynucleotide building block of which DNA is made. 2'-Deoxycytidine-5'-monophosphate can be used as a substrate of UMP/CMP kinase to form dCDP upon phosphorylation to dCTP and supports DNA biosynthesis .

HY-W009216R

2'-Deoxycytidine-5'-monophosphate (Standard) 5'-dCMP (Standard); Deoxy-CMP (Standard); 2'-Deoxycytidine-5'-monophosphoric acid (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
2'-Deoxycytidine-5'-monophosphoric acid (Standard) is the analytical standard of 2'-Deoxycytidine-5'-monophosphoric acid. This product is intended for research and analytical applications. 2'-Deoxycytidine-5'-monophosphate (2'-Deoxycytidine-5'-monophosphoric acid) is an endogenous metabolite. 2'-Deoxycytidine-5'-monophosphate is a deoxynucleotide building block of which DNA is made. 2'-Deoxycytidine-5'-monophosphate can be used as a substrate of UMP/CMP kinase to form dCDP upon phosphorylation to dCTP and supports DNA biosynthesis .

Clofarabine-5'-triphosphate trisodium	DNA/RNA Synthesis	Cancer
Clofarabine-5'-triphosphate trisodium is the trisodium salt form of Clofarabine-5'-triphosphate (HY-164840). Clofarabine-5'-triphosphate trisodium is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-triphosphate trisodium exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair .

Clofarabine-5'-triphosphate Clofarabine-TP	DNA/RNA Synthesis	Cancer
Clofarabine-5'-triphosphate is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-triphosphate exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair .

Antitumor agent-152	DNA/RNA Synthesis	Cancer
Antitumor agent-152 (Compound 5) is a specific substrate and inhibitor of deoxycytidine kinase (dCK) with anticancer activity. Antitumor agent-152 can inhibit the uptake of ³H-dC in L1210 leukemia cells with an IC₅₀ value of 1.12 μM .

Clofarabine-5'-diphosphate Clofarabine-DP	DNA/RNA Synthesis	Cancer
Clofarabine-5'-diphosphate (Clofarabine-DP) is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-diphosphate can be further phorphorylated into Clofarabine-5'-triphosphate, and exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair .

Clofarabine-5'-diphosphate trisodium Clofarabine-DP trisodium	DNA/RNA Synthesis	Cancer
Clofarabine-5'-diphosphate trisodium (Clofarabine-DP trisodium) is the trisodium salt form of Clofarabine-5'-diphosphate (HY-164839). Clofarabine-5'-diphosphate trisodium is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-diphosphate trisodium can be further phorphorylated into Clofarabine-5'-triphosphate, and exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair .

Cytarabine 5’-monophosphate	DNA/RNA Synthesis Drug Metabolite	Cancer
Cytarabine 5′-monophosphate is a metabolite of the nucleoside analog Cytarabine (HY-13605), catalyzed by deoxycytidine kinase. Cytarabine 5′-monophosphate is incorporated into DNA by DNA polymerase α, which reduces the rate of DNA synthesis. At a concentration of 15 mM, Cytarabine 5′-monophosphate inhibits nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae (S. cerevisiae). Additionally, Cytarabine 5′-monophosphate (3.5-75.1 mg/kg) improves survival in leukemia mice (L1210 mice). Cytarabine 5′-monophosphate can be used in cancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W009216R

2'-Deoxycytidine-5'-monophosphate (Standard) 5'-dCMP (Standard); Deoxy-CMP (Standard); 2'-Deoxycytidine-5'-monophosphoric acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite	Reference Standards Endogenous Metabolite
2'-Deoxycytidine-5'-monophosphoric acid (Standard) is the analytical standard of 2'-Deoxycytidine-5'-monophosphoric acid. This product is intended for research and analytical applications. 2'-Deoxycytidine-5'-monophosphate (2'-Deoxycytidine-5'-monophosphoric acid) is an endogenous metabolite. 2'-Deoxycytidine-5'-monophosphate is a deoxynucleotide building block of which DNA is made. 2'-Deoxycytidine-5'-monophosphate can be used as a substrate of UMP/CMP kinase to form dCDP upon phosphorylation to dCTP and supports DNA biosynthesis .

Species:	Human (2)
Tag:	His (2) T7 (1)
Source:	P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	*DCK/Deoxycytidine* kinase Protein, Human (His-T7)** rHuDeoxycytidine Kinase/DCK, His-T7; Deoxycytidine Kinase; dCK; DCK	Human	E. coli
	DCK/deoxycytidine kinase protein can effectively phosphorylate deoxyribonucleosides, including deoxycytidine, deoxyguanosine and deoxyadenosine, showing broad substrate specificity and no chiral selectivity. As an indispensable enzyme, DCK plays a crucial role in phosphorylating nucleoside analogues, which is critical in antiviral and chemotherapeutic treatments. DCK/Deoxycytidine kinase Protein, Human (His-T7) is the recombinant human-derived DCK/Deoxycytidine kinase protein, expressed by E. coli , with N-6*His, N-T7 labeled tag.

	*DCK/Deoxycytidine* kinase Protein, Human (P. pastoris, His)** rHuDeoxycytidine Kinase/DCK, His-T7; Deoxycytidine Kinase; dCK; DCK	Human	P. pastoris
	DCK/deoxycytidine kinase protein can effectively phosphorylate deoxyribonucleosides, including deoxycytidine, deoxyguanosine and deoxyadenosine, showing broad substrate specificity and no chiral selectivity. As an indispensable enzyme, DCK plays a crucial role in phosphorylating nucleoside analogues, which is critical in antiviral and chemotherapeutic treatments. DCK/Deoxycytidine kinase Protein, Human (P. pastoris, His) is the recombinant human-derived DCK/Deoxycytidine kinase protein, expressed by P. pastoris , with C-6*His labeled tag.

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2'-Deoxycytidine-5'-monophosphate 1 Publications Verification 5'-dCMP; Deoxy-CMP; 2'-Deoxycytidine-5'-monophosphoric acid		Nucleosides and their Analogs C
2'-Deoxycytidine-5'-monophosphate (2'-Deoxycytidine-5'-monophosphoric acid) is an endogenous metabolite. 2'-Deoxycytidine-5'-monophosphate is a deoxynucleotide building block of which DNA is made. 2'-Deoxycytidine-5'-monophosphate can be used as a substrate of UMP/CMP kinase to form dCDP upon phosphorylation to dCTP and supports DNA biosynthesis .

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