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Results for "

D3R

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (5) Dopamine Receptor (20) Endogenous Metabolite (1) GSK-3 (1) Isotope-Labeled Compounds (3) mAChR (1) Opioid Receptor (3) P-glycoprotein (1) PERK (1) PKA (1) Potassium Channel (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (18)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-117059

SK609 hydrochloride	Dopamine Receptor	Neurological Disease
SK609 hydrochloride is a dopamine D3 receptor (D3R) selective agonist with an EC₅₀ of 1109 nM. SK609 hydrochloride has the potential for parkinson research .

HY-116820

OS-3-106	Dopamine Receptor	Neurological Disease
OS-3-106 is a potent, BBB-penetrated and selective dopamine D3 receptor (D3R) agonist. OS-3-106 binds with high affinity (K_i = 0.2 nM) at the *D3R*. OS-3-106 can be used for psychoactivator addiction research .

HY-149337

D3R ligand 1	Dopamine Receptor	Neurological Disease
D3R ligand 1 (compound 23b) is a potent and selective ligand of dopamine receptor *D3R* (Ki=66 nM), containing a THPB template. D3R ligand 1 is also an antagonist for both G-protein- and β-arrestin-based signaling .

HY-149387

D3R/MOR antagonist 2	Dopamine Receptor Opioid Receptor	Inflammation/Immunology
D3R/MOR antagonist 2 (Compound 121) is a *D3R/MOR* antagonist (K_i: 361 nM and 85.2 nM respectively). D3R/MOR antagonist 2 has the potential to produce analgesic effects through MOR partial agonism, reduce opioid-misuse liability via D3R antagonism .

HY-149386

D3R/MOR antagonist 1	Dopamine Receptor Opioid Receptor	Inflammation/Immunology
D3R/MOR antagonist 1 (Compound 114) is a *D3R/MOR* antagonist (K_i: 46.5 nM and 691 nM respectively). D3R/MOR antagonist 1 has the potential to produce analgesic effects through MOR partial agonism, reduce opioid-misuse liability via D3R antagonism .

HY-129890

7-Hydroxy-PIPAT	Dopamine Receptor	Neurological Disease
7-Hydroxy-PIPAT (compound 2) is a D3R agonist. 7-Hydroxy-PIPAT is a high affinity to D3 dopamine receptor with K_i value of 0.99 nM .

HY-156239

Dopamine D3 receptor ligand-5	Dopamine Receptor 5-HT Receptor	Neurological Disease
Dopamine D3 receptor ligand-5 (13a), a Cariprazine (HY-14763) analogue, is a dopamine D3 receptor ligand, with K_i values of 2.85 nM and 0.14 nM for D₂R and D₃R, respectively .

HY-111280

ST 198	Dopamine Receptor	Neurological Disease
ST 198 is an orally active *D3R* antagonist. ST 198 can block the expression of nicotine-induced CPP at doses selective for D3R. ST 198 can be used for the research of neurological disease .

HY-124583

PF-4363467	Dopamine Receptor	Neurological Disease
PF-4363467, a dopamine D3/D2 receptor antagonist, attenuates opioid drug-seeking behavior without concomitant D2 side effects. PF-4363467 exhibits K_i values of 3.1 nM and 692 nM for D3R and D2R .

HY-155706

MOR agonist-2	Opioid Receptor Dopamine Receptor	Inflammation/Immunology
MOR agonist-2 (compound 46) is a antagonist of *D3R* and agonist of MOR (K_i: 7.26 nM and 564 nM, respectively). MOR agonist-2 has the potential to produce analgesic effects through MOR partial agonism. MOR agonist-2 reduces opioid-misuse liability via D3R antagonism .

HY-136390

ML417 1 Publications Verification	Dopamine Receptor	Neurological Disease
ML417 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC₅₀ of 38 nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons .

HY-175505

Dopamine D3 receptor antagonist-3	Dopamine Receptor	Neurological Disease
Dopamine D3 receptor antagonist-3 is a D3 dopamine receptor (D3R)-selective positive allosteric modulator (PAM)-antagonist that can cross the blood-brain barrier. Dopamine D3 receptor antagonist-3 exhibits antagonist activity in the D3R-mediated β-arrestin recruitment assay with an IC₅₀ and a K_b of 2.5 μM and 0.49 μM. amine D3 receptor antagonist-3 is also an antagonist in the D3R-mediated Go-BRET assay with an IC₅₀ of 0.34 μM. Dopamine D3 receptor antagonist-3 can be used for the study of neuropsychiatric disorders, including substance use disorder .

HY-175504

MLS6357	Dopamine Receptor PERK	Neurological Disease
MLS6357 is a D3 dopamine receptor (D3R)-selective positive allosteric modulator (PAM)-antagonist. MLS6357 exhibits antagonist activity in the D3R-mediated and the BRET-based β-arrestin recruitment assay with IC₅₀s of 13 and 14 μM, and no activity for other DAR subtypes (D1R/D2R/D4R/D5R) (IC₅₀ > 100 μM). MLS6357 is also an antagonist in the D3R-mediated Go-BRET assay with an IC₅₀ of 17 μM. MLS6357 can be used for the study of neuropsychiatric disorders, including substance use disorder .

HY-155707

MOR agonist-3	Dopamine Receptor	Inflammation/Immunology
MOR agonist-3 (Compound 84) is a *D3R/MOR* antagonist/partial agonist a(K_i 382 nM and 55.2 nM respectively). MOR agonist-3 has the potential to produce analgesic effects through MOR (μ-opioid receptor) (HY-149337) partial agonists and to reduce opioid abuse through D3R antagonists. MOR agonist-3 can be used in the treatment of inflammation and neuropathic pain research .

HY-10847B

SB-277011 hydrochloride 1 Publications Verification SB-277011A hydrochloride	Dopamine Receptor 5-HT Receptor	Neurological Disease
SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D₃ receptor (D₃R) antagonist with K_i values of 10.7 nM and 11.2 nM at rodent and human D₃R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with pK_is of 8.0, 6.0, <5.2, and 5.9 for D3, D2, 5-HT_1B, and 5-HT_1D receptors, respectively .

HY-119768

(±)-BAK2-66	Dopamine Receptor	Neurological Disease
(±)-BAK2-66 is a selectivity dopamine D3 receptor antagonist with theK_i values of 1nM and 960 nM for D3R and D2R, respectively. (±)-BAK2-66 can be used for study in animal models of addiction .

HY-176287

ARN25657	Dopamine Receptor GSK-3 PKA P-glycoprotein	Neurological Disease
ARN25657 is a dual-acting *D3R/GSK-3β* modulator. ARN25657 has both partial D3R agonist activity (EC₅₀ = 15.2 nM, K_i=1.5 nM) and potent *GSK-3β* inhibitor activity (IC₅₀ = 19.3 nM). ARN25657 exhibits excellent GSK-3β selectivity over FYN, PKA, and CDK5/p35. ARN25657 inhibits P-glycoprotein (P-gP)-mediated acetoxymethyl calcein efflux and improves in vitro ADME properties while maintaining a balanced dual-target profile. ARN25657 is useful for studying bipolar disorder and related neuropsychiatric disorders .

HY-109167

Aramisulpride (R)-Amisulpride; (R)-Esamisulpride; (R)-DAN 2163	Dopamine Receptor 5-HT Receptor	Neurological Disease
Aramisulpride (R-(+)-Amisulpride) is the R-isomer of Amisulpride (HY-14545). Aramisulpride is a 5-HT₇ receptor antagonist with a K_i value of 22 nM. Aramisulpride is a *D₂/D₃* receptor antagonist with a K_i value of 140 nM for D₂R and a K_i value of 13.9 nM for *D₃R*. Aramisulpride can be used in psychiatric research .

HY-126068

Esamisulpride (S)-Amisulpride; (S)-Aramisulpride; (S)-DAN 2163	Dopamine Receptor 5-HT Receptor	Neurological Disease
Esamisulpride ((S)-Amisulpride) is the S-isomer of Amisulpride (HY-14545). Esamisulpride is a potent dopamine *D₂/D₃* receptor antagonist with K_i values of 4.43 nM for D₂R and 0.72 nM for *D₃R. Esamisulpride is a 5-HT₇* receptor antagonist with a K_i of 900 nM. Esamisulpride can be used in the research of schizophrenia and depression ^[3].

HY-109743

BP14979	Dopamine Receptor	Neurological Disease
BP14979 is a dopamine D3 receptor agonist with activity in the study of neurological diseases. BP14979 can be used to develop ligands with higher selectivity and affinity for D3 receptors. The structural characteristics of BP14979 make it potential in modulating the efficacy of D3 receptors. The design of BP14979 is based on the difference in efficacy with D3R selective antagonists, providing opportunities for optimizing new drug development .

HY-175532

M4 mAChR Modulator-2	mAChR	Neurological Disease
M4 mAChR Modulator-2 is an orally active, selective, brain-penetrant positive allosteric modulator (PAM) of the M4 muscarinic acetylcholine receptor (M4 mAChR) (EC₅₀ = 513 nM). M4 mAChR Modulator-2 exhibits high target selectivity, showing negligible affinity and low inhibition rates for non-target receptors (D1R/D2R/D3R, 5-HT subtypes, κ/δ/μ opioid receptors, H1, M1/M2) while specifically binding to M4 mAChR with a K_i of 377 nM and an inhibition rate of 62.8%. M4 mAChR Modulator-2 reverses Dizocilpine (MK-801) (HY-15084B)-induced hyperlocomotion in mice. M4 mAChR Modulator-2 can be used for the study of schizophrenia

HY-RS04001

Drd3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Drd3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Drd3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Drd3 Mouse Pre-designed siRNA Set A Drd3 Mouse Pre-designed siRNA Set A

HY-W778023

(R)-2-(3-Benzoylphenyl)propanoic acid-13C,d3 (R)-(-)-Ketoprofen-¹³C,d₃	Isotope-Labeled Compounds	Others
(R)-2-(3-Benzoylphenyl)propanoic acid- ¹³C,d₃ ((R)-(-)-Ketoprofen- ¹³C,d₃) is the deuterium labeled and ¹³C-labeled Ketoprofen-d₃-1 (HY-W322573S).

HY-144856S1

Sapropterin-d3 (6R)-BH4-d₃; (6R)-Tetrahydro-L-biopterin-d₃	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Sapropterin-d₃ ((6R)-BH4-d₃) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) .

HY-W777120

Cisapride-13C,d3 R 51619-13C,d3; (±)-Cisaprid-_{13_{C_,d₃}}	Isotope-Labeled Compounds 5-HT Receptor Potassium Channel	Neurological Disease
Cisapride- ¹³C,d₃ (R 51619- ¹³C,d₃) is the deuteriumand ¹³C-labeled Cisapride (HY-14149). Cisapride (R 51619) is an orally active 5-HT4 receptor agonist with an EC₅₀ value of 140 nM. Cisapride is a hERG blocker with an IC₅₀ value of 9.4 nM. Cisapride is a gastroprokinetic agent that stimulates gastrointestinal motor activity ^[3] .

Cat. No.	Product Name	Chemical Structure

HY-W778023

(R)-2-(3-Benzoylphenyl)propanoic acid-13C,d3
(R)-2-(3-Benzoylphenyl)propanoic acid- ¹³C,d₃ ((R)-(-)-Ketoprofen- ¹³C,d₃) is the deuterium labeled and ¹³C-labeled Ketoprofen-d₃-1 (HY-W322573S).

HY-144856S1

Sapropterin-d3
Sapropterin-d₃ ((6R)-BH4-d₃) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) .

HY-W777120

Cisapride-13C,d3
Cisapride- ¹³C,d₃ (R 51619- ¹³C,d₃) is the deuteriumand ¹³C-labeled Cisapride (HY-14149). Cisapride (R 51619) is an orally active 5-HT4 receptor agonist with an EC₅₀ value of 140 nM. Cisapride is a hERG blocker with an IC₅₀ value of 9.4 nM. Cisapride is a gastroprokinetic agent that stimulates gastrointestinal motor activity ^[3] .

Drd3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Drd3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Drd3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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