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Collagen cross-link

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By Targets:	Collagen (1) Amino Acid Derivatives (1) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (2) Endogenous Metabolite (2) FAK (1) Isotope-Labeled Compounds (1) Lipoxygenase (1) MMP (2) Monoamine Oxidase (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Collagen

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-29035

Dopamine acrylamide	Collagen	Others
Dopamine acrylamide, a polyphenol derivative, can cross-link collagen mainly via noncovalent bonding under acidic-non-oxidized conditions .

HY-107829

3-Aminopropionitrile fumarate (2:1) 5 Publications Verification Di-β-aminopropionitrile fumarate; β-Aminopropionitrile fumarate; β-Ammoniumpropionitrile hemifumarate	MMP	Others
3-Aminopropionitrile fumarate (2:1) is a lathyrogen which inhibits crosslinking of *collagen*.

HY-113403

Pyridinoline	Endogenous Metabolite	Others
Pyridinoline, a fluorescent material, is a bone resorption biomarker. Pyridinoline also is a type crosslink of collagen .

HY-151498A

PXS-4787 hydrochloride	Monoamine Oxidase	Others
PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 hydrochloride inhibits LOX with IC₅₀s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively. PXS-4787 hydrochloride reduces deposition and crosslinking of collagen I secreted by human fibroblasts .

HY-W740191

Dihydroxylysinonorleucine DHLNL	Biochemical Assay Reagents	Others
Dihydroxylysinonorleucine is a reducible lysine-derived cross-link. Dihydroxylysinonorleucine can be used for the cross-linking of Collagen .

HY-113115A

L-Allysine	Amino Acid Derivatives	Cancer
L-Allysine is an oxidized derivative of lysine, produced by lysine oxidase (LOX). L-Allysine plays a key role in the cross-linking of collagen in fibrotic reactions. L-Allysine can be used in the study of pancreatic cancer.

HY-P0284

C-telopeptide	MMP	Inflammation/Immunology
C-telopeptide, a cross-linked peptide of type I collagen, is released during bone resorption and has been correlated with bone mineral density (BMD).

HY-171955

LXG6403	Lipoxygenase Apoptosis Reactive Oxygen Species (ROS) FAK	Cancer
LXG6403 is an orally active and irreversible LOX inhibitor (IC₅₀ = 1.3 μM). LXG6403 is ~3.5-fold more specific for LOX than LOXL2 and does not inhibit LOXL1. LXG6403 inhibits FAK signaling and induces ROS generation and DNA damage, leading to G1 arrest and apoptosis in chemoresistant triple-negative breast cancer (TNBC) cell lines. LXG6403 alters the extracellular matrix (ECM) and collagen structure, reducing collagen cross-linking and deposition, thereby increasing drug penetration and reducing tumor stiffness. LXG6403 overcomes Doxorubicin resistance in chemoresistant TNBC PDX in vivo and can be used to study high-stiffness resistant tumors .

HY-P6172

GCO-(GPO)10-GCOG	Bacterial	Infection
GCO-(GPO)10-GCOG is a GPO repeat-containing peptide with a single collagen triple helix structure similar to *collagen. The cross-linked* triple helix GCO-(GPO)10-GCOG can form a collagen-related peptide (CRP) mimetic that tightly binds to the Yersinia adhesin YadA. YadA mediates the adhesion of the human enteric pathogen Yersinia enterocolitica to collagen and other extracellular matrix components, potentially interfering with host processes mediated by endogenous collagen-binding proteins in vivo. GCO-(GPO)10-GCOG can be used to study YadA-associated infections .

HY-W738852

Hydroxylysylpyridinoline-d6	Isotope-Labeled Compounds Endogenous Metabolite	Others
Hydroxylysylpyridinoline-d₆ is deuterium labeled Pyridinoline. Pyridinoline, a fluorescent material, is a bone resorption biomarker. Pyridinoline also is a type crosslink of collagen .

HY-Y0623

N-Hydroxysuccinimide 1 Publications Verification HOSu; 1-Hydroxy-2,5-pyrrolidinedione	Biochemical Assay Reagents	Others
N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering .

Cat. No.	Product Name	Type

HY-Y0623

N-Hydroxysuccinimide 1 Publications Verification HOSu; 1-Hydroxy-2,5-pyrrolidinedione	Biochemical Assay Reagents
N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering .

N-Hydroxysuccinimide

1 Publications Verification

HOSu; 1-Hydroxy-2,5-pyrrolidinedione

Biochemical Assay Reagents

N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering .

Cat. No.	Product Name	Target	Research Area

HY-P0284

C-telopeptide	MMP	Inflammation/Immunology
C-telopeptide, a cross-linked peptide of type I collagen, is released during bone resorption and has been correlated with bone mineral density (BMD).

HY-P6172

GCO-(GPO)10-GCOG	Bacterial	Infection
GCO-(GPO)10-GCOG is a GPO repeat-containing peptide with a single collagen triple helix structure similar to *collagen. The cross-linked* triple helix GCO-(GPO)10-GCOG can form a collagen-related peptide (CRP) mimetic that tightly binds to the Yersinia adhesin YadA. YadA mediates the adhesion of the human enteric pathogen Yersinia enterocolitica to collagen and other extracellular matrix components, potentially interfering with host processes mediated by endogenous collagen-binding proteins in vivo. GCO-(GPO)10-GCOG can be used to study YadA-associated infections .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113403

Pyridinoline	Structural Classification Animals Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite
Pyridinoline, a fluorescent material, is a bone resorption biomarker. Pyridinoline also is a type crosslink of collagen .

Cat. No.	Product Name	Chemical Structure

HY-W738852

Hydroxylysylpyridinoline-d6
Hydroxylysylpyridinoline-d₆ is deuterium labeled Pyridinoline. Pyridinoline, a fluorescent material, is a bone resorption biomarker. Pyridinoline also is a type crosslink of collagen .

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Collagen cross-link

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products