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Results for "

CRD

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

2

Peptides

1

Natural
Products

2

Isotope-Labeled Compounds

3

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14656
    Diltiazem hydrochloride
    Maximum Cited Publications
    8 Publications Verification

    CRD-401

    		 Calcium Channel Cardiovascular Disease Cancer
    Diltiazem hydrochloride is a Ca 2+ influx inhibitor (slow channel blocker or calcium antagonist).
    Diltiazem hydrochloride
  • HY-P1454
    Fz7-21
    3 Publications Verification

    Ac-LPSDDLEFWCHVMY-NH2

    		 Wnt Cancer
    Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids .
    Fz7-21
  • HY-P1454A
    Fz7-21 TFA
    3 Publications Verification

    Ac-LPSDDLEFWCHVMY-NH2 TFA

    		 Wnt Cancer
    Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 TFA impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids .
    Fz7-21 TFA
  • HY-12307
    (-)-Indolactam V
    2 Publications Verification

    Indolactam V

    		 PKC Cancer
    (-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.
    (-)-Indolactam V
  • HY-14656S3
    Diltiazem-d5 hydrochloride

    CRD-401-d5 hydrochloride

    		 Calcium Channel Isotope-Labeled Compounds Cardiovascular Disease
    Diltiazem-d5 (CRD-401-d5) hydrochloride is deuterium-labeled Diltiazem (hydrochloride) (HY-14656) .
    Diltiazem-d5 hydrochloride
  • HY-14656S2
    Diltiazem-d6 hydrochloride

    CRD-401-d6 hydrochloride

    		 Isotope-Labeled Compounds Calcium Channel Cardiovascular Disease Cancer
    Diltiazem-d6 (hydrochloride) (CRD-401-d6 (hydrochloride)) is deuterium labeled Diltiazem (hydrochloride). Diltiazem hydrochloride is a Ca 2+ influx inhibitor (slow channel blocker or calcium antagonist).
    Diltiazem-d6 hydrochloride
  • HY-14656R
    Diltiazem hydrochloride (Standard)

    CRD-401 (Standard)

    		 Reference Standards Calcium Channel Cardiovascular Disease Cancer
    Diltiazem (hydrochloride) (Standard) is the analytical standard of Diltiazem (hydrochloride). This product is intended for research and analytical applications. Diltiazem hydrochloride is a Ca 2+ influx inhibitor (slow channel blocker or calcium antagonist).
    Diltiazem hydrochloride (Standard)
  • HY-133974
    7-keto-25-Hydroxycholesterol

    7-keto-25-OHC

    		 Smo Cancer
    7-keto-25-Hydroxycholesterol (7-keto-25-OHC), a oxysterol, is a Smoothened (Smo) activator. 7-keto-25-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo .
    7-keto-25-Hydroxycholesterol
  • HY-162372
    Hedgehog IN-6

    		Hedgehog Smo Cancer
    Hedgehog IN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor that can be used in cancer research. Hedgehog IN-6 inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterization .
    Hedgehog IN-6
  • HY-RS03203
    CRX Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CRX Human Pre-designed siRNA Set A contains three designed siRNAs for CRX gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CRX Human Pre-designed siRNA Set A
    CRX Human Pre-designed siRNA Set A
  • HY-RS12154
    RPGR Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    RPGR Human Pre-designed siRNA Set A contains three designed siRNAs for RPGR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RPGR Human Pre-designed siRNA Set A
    RPGR Human Pre-designed siRNA Set A
  • HY-12316
    20(S)-Hydroxycholesterol
    2 Publications Verification

    20α-Hydroxycholesterol

    		 Smo Endogenous Metabolite Cardiovascular Disease Metabolic Disease Cancer
    20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC50 of ~30 μM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis .
    20(S)-Hydroxycholesterol

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