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CRBN-6-5-5-VHL

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136262
    CRBN-6-5-5-VHL

    		PROTACs E1/E2/E3 Enzyme Cancer
    CRBN-6-5-5-VHL is a potent and selective von Hippel-Lindau-based cereblon (CRBN) degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL has almost no effect on the degradation of the neo-substrates IKZF1 and IKZF3. (Pink: VHL ligand (HY-125845); Blue: E3 Ligase ligand (HY-10984); Black: linker (HY-403544)) .
    CRBN-6-5-5-VHL
  • HY-403544
    CbzNH-(C5-O)2-C4-Boc

    		PROTAC Linkers Others
    CbzNH-(C5-O)2-C4-Boc is a PROTAC linker. CbzNH-(C5-O)2-C4-Boc can be used for the synthesis of PROTAC CRBN-6-5-5-VHL (HY-136262) .
    CbzNH-(C5-O)2-C4-Boc

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