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CHK1-IN-12

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-171785
    CHK1-IN-12

    		Checkpoint Kinase (Chk) Apoptosis Cancer
    CHK1-IN-12 (Compound example 1-5) is an orally active and highly selective checkpoint kinase 1 (CHK1) inhibitor with in vitro enzyme IC50≤10 nM and cellular IC50≤50 nM. CHK1-IN-12 inhibits the phosphorylation activity of CHK1 kinase to block the DNA damage response pathway, inducing tumor cell cycle arrest and apoptosis. CHK1-IN-12 is promising for research of cancers .
    CHK1-IN-12

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