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Isoforms Recommended:	CCR8

Results for "

CCR8

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CCR (24) mRNA (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (9) Endocrinology (5) Inflammation/Immunology (13) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) mRNA (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144200

CCR8 antagonist 2	CCR	Neurological Disease Cancer
CCR8 antagonist 2 is a potent antagonist of *CCR8. CCR8* (C-C Motif Chemokine Receptor 8) is predominantly expressed on Treg cells and Th2 cells, but not on Th1 cells. CCR8 antagonist 2 inhibits CCR8 activity, which may be used in the research of diseases mediated by CCR8, such as cancer, and/or neuropathic pain (extracted from patent WO2022000443A1, compound 220) .

HY-144197

CCR8 antagonist 1	CCR	Neurological Disease
CCR8 antagonist 1 (Compound 15) is a potente human *CCR8* antagonist with a K_i of 1.6 nM. CCR8 antagonist 1 has high safety and metabolic stability. CCR8 antagonist 1 can be used to study diseases such as asthma and multiple sclerosis .

HY-122219

R243 2 Publications Verification	CCR	Inflammation/Immunology
R243 is a potent and selective *CCR8* antagonist. R243 inhibits *CCL₁/CCR8* interaction and inhibits *CCR8* signaling and chemotaxis. R243 has antinociceptive and anti-inflammatory effects .

HY-RS02170

Ccr8 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CCR	Others
Ccr8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccr8 Mouse Pre-designed siRNA Set A Ccr8 Mouse Pre-designed siRNA Set A

HY-RS02169

CCR8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CCR	Others
CCR8 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCR8 Human Pre-designed siRNA Set A CCR8 Human Pre-designed siRNA Set A

HY-160647

CCR8 antagonist 3	CCR	Inflammation/Immunology
CCR8 antagonist 3 (compound 2) is a *CCR8* antagonist with an IC₅₀ value of 0.062 µM. CCR8 antagonist 3 shows human microsomal stability .

HY-RS02171

Ccr8 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ccr8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ccr8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ccr8 Rat Pre-designed siRNA Set A Ccr8 Rat Pre-designed siRNA Set A

HY-174741

*Human CCR8* mRNA**	mRNA	Inflammation/Immunology
Human CCR8 mRNA encodes the human C-C motif chemokine receptor 8 (CCR8) protein, a member of the beta chemokine receptor family. CCR8 plays a role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues.

HY-176799

LMD-584	CCR	Others
LMD-584 is an agonist of *CCR8*. LMD-584 is also an analog of LMD-009 (HY-121885) .

HY-P991135

Enzelkitug	CCR	Cancer
Enzelkitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the human C-C motif chemokine receptor 8 (CCR8). Enzelkitug is promising for research of various solid tumors and hematological malignancies .

HY-P991061

Tagmokitug CHS-114; SRF-114	CCR	Cancer
Tagmokitug (CHS-114) is a fully human IgG1 antibody that targets *CCR8*. Tagmokitug has the potential for the study of head and neck squamous cell carcinoma (HNSCC). The isotype control for Tagmokitug can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-124416

ML604086 1 Publications Verification	CCR	Inflammation/Immunology Endocrinology
ML604086 is a selective *CCR8* inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca ²⁺ concentrations .

HY-153670

IPG7236	CCR	Cancer
IPG7236 is a selective and orally active CC chemokine receptor 8 (CCR8) antagonist with an IC₅₀ of 24 nM in a Tango assay. IPG7236 effectively inhibits the downstream signaling of CCR8 induced by CCL1 (IC₅₀ = 8.44 nM), CCL1-induced downstream signaling in the CCR8-overexpressing cells (IC₅₀ = 24.3 nM), and CCL1-induced CCR8 ⁺ Treg cells’ migration (IC₅₀ = 33.8 nM) .IPG7236 demonstrates an anti-cancer effect via up-regulating T_reg and down-regulating cytotoxic T (CD8 ⁺ T) cells. IPG7236 can used for the study of breast cancer .

HY-101038A

ZK756326 dihydrochloride 1 Publications Verification	CCR	Endocrinology Cancer
ZK756326 dihydrochloride is a nonpeptide chemokine receptor agonist for the CC chemokine receptor *CCR8*.

HY-101038

ZK 756326	CCR	Endocrinology Cancer
ZK756326 is a nonpeptide chemokine receptor agonist for the CC chemokine receptor *CCR8*.

HY-176800

LMD-902	CCR	Neurological Disease Inflammation/Immunology
LMD-902, a LMD-009 (HY-121885) analog, is a *CCR8* agonist with an EC₅₀ of 15  nM. LMD-902 has a superior binging capacity depending on key residues such as PheVI:16. LMD-902 can be used for inflammation diseases like bronchial asthma and central nervous system diseases like multiple sclerosis research .

HY-153669

SB-649701	CCR	Inflammation/Immunology
SB-649701 is a potent human CCR8 antagonist, with a pIC₅₀ of 7.7. AZ084 can be used for the research of asthma .

HY-P990904

Azirkitug	CCR	Inflammation/Immunology
HY-P990904 is an *CCR8*-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990914

Denikitug	CCR	Inflammation/Immunology
HY-P990914 is an *CCR8*-targeting IgG1κ type chimeric antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990908

Cafelkibart	CCR	Inflammation/Immunology
HY-P990908 is an *CCR8*-targeting IgG1κ type chimeric antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991481

S-531011	CCR	Cancer
S-531011 is a human IgG1 monoclonal antibody (mAb) targeting *CCR8. S-531011 reduces tumor-infiltrating CCR8*+ Tregs and has anti-tumor activity in CT26.WT and EMT6 tumor-bearing mouse tumor models. S-531011 can be used in the study of cancer immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990923

Lanerkitug	CCR	Inflammation/Immunology
HY-P990923 is an *CCR8*-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) .

HY-160658

AZ760	CCR	Inflammation/Immunology
AZ760 is a *CCR8* antagonist. AZ760 shows excellent potency, good lipophilicity and high free fraction in blood. AZ760 exhibits unacceptable hERG inhibition .

HY-121885

LMD-009 2 Publications Verification	CCR	Metabolic Disease Endocrinology
LMD-009 is a selective *CCR8* nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC₅₀s from 11 to 87 nM .

HY-P991520

LM-108	CCR	Cancer
LM-108 is an anti-CCR8 monoclonal antibody. LM-108 selectively depletes tumor-infiltrating targeting tumor-infiltrating regulatory T cells (Tregs). LM-108 can be used for the study of gastric cancer .

HY-119217

AZ084 2 Publications Verification	CCR	Inflammation/Immunology Endocrinology Cancer
AZ084 is a potent, selective, allosteric and oral active *CCR8* allosteric antagonist, with a K_i of 0.9 nM. Has potential to treat asthma . AZ084 restrains the formation of the immunologically tolerant pre-metastatic niche (PMN) and tumor cells metastasis in lung by downregulating Treg differentiation. AZ084 can be used in studies of asthma and cancer .

Cat. No.	Product Name	Target	Research Area

HY-P991001

Imzokitug BMS-986340; CCR8.50	Inhibitory Antibodies	Inflammation/Immunology
HY-P991001 is an CKR-L1-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990904

Azirkitug	CCR	Inflammation/Immunology
HY-P990904 is an *CCR8*-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990914

Denikitug	CCR	Inflammation/Immunology
HY-P990914 is an *CCR8*-targeting IgG1κ type chimeric antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990908

Cafelkibart	CCR	Inflammation/Immunology
HY-P990908 is an *CCR8*-targeting IgG1κ type chimeric antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991135

Enzelkitug	CCR	Cancer
Enzelkitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the human C-C motif chemokine receptor 8 (CCR8). Enzelkitug is promising for research of various solid tumors and hematological malignancies .

HY-P991061

Tagmokitug CHS-114; SRF-114	CCR	Cancer
Tagmokitug (CHS-114) is a fully human IgG1 antibody that targets *CCR8*. Tagmokitug has the potential for the study of head and neck squamous cell carcinoma (HNSCC). The isotype control for Tagmokitug can refer to Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991481

S-531011	CCR	Cancer
S-531011 is a human IgG1 monoclonal antibody (mAb) targeting *CCR8. S-531011 reduces tumor-infiltrating CCR8*+ Tregs and has anti-tumor activity in CT26.WT and EMT6 tumor-bearing mouse tumor models. S-531011 can be used in the study of cancer immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990923

Lanerkitug	CCR	Inflammation/Immunology
HY-P990923 is an *CCR8*-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) .

HY-P991520

LM-108	CCR	Cancer
LM-108 is an anti-CCR8 monoclonal antibody. LM-108 selectively depletes tumor-infiltrating targeting tumor-infiltrating regulatory T cells (Tregs). LM-108 can be used for the study of gastric cancer .

Recombinant Proteins Recommended:

CCR8

Species:	Human (2) Cynomolgus (1)
Tag:	His (2) Myc (1) Fc (1)
Source:	HEK293 (2) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P700965

	CCR8 Protein, Cynomolgus (HEK293, mFc) CCR-8; CMKBRL2; CKR-L1; GPR-CY6; GPRCY6; TER1; CCR8; CKRL1; CMKBR8; CD198; ChemR1; CKR-L1; CY6; TER-1; CDw198	Cynomolgus	HEK293
	CCR8 is part of the G-protein coupled receptor 1 family. CCR8 Protein, Cynomolgus (HEK293, mFc) is the recombinant cynomolgus-derived CCR8 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P700400

	CCR8 Protein-VLP, Human (HEK293, His) CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973	Human	HEK293
	CCR8 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P700543

	CCR8 Protein, Human (P. pastoris, His, Myc) CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973	Human	P. pastoris
	CCR8 Protein-VLP, a receptor for CCL1/SCYA1/I-309, may regulate monocyte chemotaxis and thymic cell line apoptosis. It also acts as an alternative coreceptor with CD4 for HIV-1 infection, facilitating viral entry. The interaction with CCL1 highlights its role in mediating cellular responses to this chemokine, implying a regulatory function in immune and inflammatory processes. CCR8 Protein, Human (P. pastoris, His) is the recombinant human-derived CCR8 protein, expressed by P. pastoris , with C-Myc, C-6*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81628

	CCR8 Antibody (YA1373) CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; TER1	FC, ELISA	Human
	CCR8 Antibody (YA1373) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CCR8.