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CAII/VII-IN-1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-178362
    CAII/VII-IN-1

    		Carbonic Anhydrase NKCC mTOR Neurological Disease
    CAII/VII-IN-1 is an orally active hCA II (KI = 12.3 nM), and hCA VII (KI = 22.6 nM) inhibitor, showing no significant activity against hCA I. CAII/VII-IN-1 shows excellent neuroprotective activity in vivo Pilocarpine (HY-B0726A)-induced seizure model. CAII/VII-IN-1 can upregulate KCC2 and inhibit mTOR, exerting neuroprotective effects. CAII/VII-IN-1 does not show any significant neurotoxic effects or alterations in liver and kidney function. CAII/VII-IN-1 can be used for the study of epilepsy .
    CAII/VII-IN-1

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