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Benzothiazole

" in MedChemExpress (MCE) Product Catalog:

39

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2

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2

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W012634
    Benzothiazole

    		Bacterial Infection Metabolic Disease Inflammation/Immunology Cancer
    Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent [1][2][3][4].
    Benzothiazole
  • HY-W012634S
    Benzothiazole-d4

    		Isotope-Labeled Compounds Bacterial Cancer
    Benzothiazole-d4 is a deuterium labeled Benzothiazole (HY-W012634). Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral .
    Benzothiazole-d4
  • HY-W019633
    Benzothiazole-5-boronic acid pinacol ester

    		Biochemical Assay Reagents Others
    Benzothiazole-5-boronic acid pinacol ester is a compound that can be used in the boronate part of Suzuki coupling reactions .
    Benzothiazole-5-boronic acid pinacol ester
  • HY-10862
    FAAH inhibitor 1

    Benzothiazole analog 3

    		 FAAH Autophagy Cancer
    FAAH inhibitor 1 (Benzothiazole analog 3) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 18±8 nM .
    FAAH inhibitor 1
  • HY-139432
    2-(Morpholinothio)benzothiazole

    		Biochemical Assay Reagents Others
    2-(Morpholinothio)benzothiazole is an accelerator that can be used for amperometric measurements .
    2-(Morpholinothio)benzothiazole
  • HY-145766
    Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine

    		Others Others
    Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine is an active compound .
    Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine
  • HY-W012634R
    Benzothiazole (Standard)

    		Reference Standards Bacterial Infection Metabolic Disease Inflammation/Immunology Cancer
    Benzothiazole (Standard) is the analytical standard of Benzothiazole. This product is intended for research and analytical applications. Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent .
    Benzothiazole (Standard)
  • HY-163826
    Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph

    		Ligands for E3 Ligase Cancer
    Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph is a ligand for E3 ubiquitin ligase. Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph can be connected to the ligand for protein by a linker to form 22-SLF (HY-163807) .
    Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph
  • HY-151536
    meso-Benzothiazole-BODIPY 505/515

    		Fluorescent Dye Neurological Disease
    meso-Benzothiazole-BODIPY 505/515 is a boron dipyrromethenes (BODIPY) -based fluorescent probeBenzothiazole-BODIPY 505/515 can monitor cellular viscosity changes and autophagy. meso-Benzothiazole-BODIPY 505/515 can be used for the research of Alzheimer’s diseases, lysosomal storage diseases and neural degeneration diseases .
    meso-Benzothiazole-BODIPY 505/515
  • HY-141043
    N,N'-bis-(Acid-PEG3)-benzothiazole Cy5

    		PROTAC Linkers Cancer
    N,N'-bis-(Acid-PEG3)-benzothiazole Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    N,N'-bis-(Acid-PEG3)-benzothiazole Cy5
  • HY-145755
    Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine

    		Biochemical Assay Reagents Others
    Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine alters the lifespan of a eukaryotic organism .
    Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine
  • HY-141038
    N-(m-PEG4)-N'-(Acid-PEG3)-benzothiazole Cy5

    		PROTAC Linkers Cancer
    N-(m-PEG4)-N'-(Acid-PEG3)-benzothiazole Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    N-(m-PEG4)-N'-(Acid-PEG3)-benzothiazole Cy5
  • HY-141064
    N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5

    		PROTAC Linkers Cancer
    N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5
  • HY-D2344
    3-BTD

    3-Benzothiazole-daphnetin

    		 Fluorescent Dye Others
    3-BTD (3-Benzothiazole-daphnetin) is a Catechol-O-methyltransferase (COMT) two-photon fluorescence probe. 3-BTD can also be used for biological imaging of endogenous COMT in living cells and tissue sections .
    3-BTD
  • HY-19054
    CGP-20376

    		Parasite Infection
    CGP-20376, a 5-methoxyl-6-dithiocarbamic-S- (2-carboxy-ethyl) ester derivative of Benzothiazole (HY-W012634), is an orally active and potent antifilarial drug. CGP-20376 has anthelmintic activity .
    CGP-20376
  • HY-134801
    CID1231538

    		GPR35 Metabolic Disease Inflammation/Immunology
    CID1231538, a benzothiazole analog, is a potent GPR35 antagonist with no significant activity against rodent orthologs of GPR35, which is also a G protein-coupled receptor (GPCR) .
    CID1231538
  • HY-120622
    BMS-243117

    		Src Cancer
    BMS-243117 is a potent, and selective benzothiazole based p56 Lck inhibitor with an IC50 of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL (human peripheral blood T-cells) proliferation with an IC50 of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck .
    BMS-243117
  • HY-147973
    IZTZ-1

    		c-Myc Apoptosis Cancer
    IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research .
    IZTZ-1
  • HY-151581
    HCVcc-IN-1

    		Virus Protease Infection
    HCVcc-IN-1 is a benzothiazole-2-thiophene S-glycoside derivative with low toxic and antiviral activity .
    HCVcc-IN-1
  • HY-151588
    Anticancer agent 90

    		Virus Protease Cancer
    Anticancer agent 90 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor activity. Anticancer agent 90 has high inhibition against the two cell line from ovarian cancer (OVCAR-4), renal cancer (A498) .
    Anticancer agent 90
  • HY-151592
    Anticancer agent 91

    		Antibiotic Cancer
    Anticancer agent 91 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor and antiviral activity. Anticancer agent 91 has high inhibition against the two cell line from CNS cancer (SF-539 and SNB-75) .
    Anticancer agent 91
  • HY-151587
    Anticancer agent 89

    		Others Cancer
    Anticancer agent 89 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor activity, has high inhibition against the three cell line from ovarian cancer (OVCAR-4), renal cancer (A498), and melanoma (SK-MEL-5) .
    Anticancer agent 89
  • HY-105084
    Lubeluzole

    		Sodium Channel Calcium Channel Infection Cardiovascular Disease Neurological Disease Cancer
    Lubeluzole is the S-isomer of benzothiazole derivative. Lubeluzole can inhibit glutamate release, glutamate-activated NO synthesis and block voltage-gated Sodium Channel and Calcium Channel. Lubeluzole exhibits anti-ischemic and neuroprotective effects. Lubeluzole also shows anti-bacterial and anti-diarrheal potential. Lubeluzole can inhibit cardiac sodium channel and prolong cardiac action potential. Lubeluzole can inhibit cancer cells proliferation and invasion and shows chemosensitizing effect. Lubeluzole can be used for the researches of cancer, infection, neurological and cardiovascular disease such as stroke, infectious diarrhea and ovarian .
    Lubeluzole
  • HY-173263
    AChE-IN-86

    		Cholinesterase (ChE) Neurological Disease
    AChE-IN-86 (Compound 6f) is an inhibitor of enzyme acetylcholinesterase (AChE) with IC50 values of 25.33 μg/mL. AChE-IN-86 exerts inhibitory activity against AChE through forming hydrogen bonds, π-π and π-alkyl interactions with amino acid residues at the key catalytic sites of AChE. AChE-IN-86 can be used for Alzheimer's disease study .
    AChE-IN-86
  • HY-105084A
    Lubeluzole dihydrochloride

    		Sodium Channel Calcium Channel Infection Cardiovascular Disease Neurological Disease Cancer
    Lubeluzole dihydrochloride is the dihydrochloride salt of Lubeluzole (HY-105084). Lubeluzole is the S-isomer of benzothiazole derivative. Lubeluzole can inhibit glutamate release, glutamate-activated NO synthesis and block voltage-gated Sodium Channel and Calcium Channel. Lubeluzole exhibits anti-ischemic and neuroprotective effects. Lubeluzole also shows anti-bacterial and anti-diarrheal potential. Lubeluzole can inhibit cardiac sodium channel and prolong cardiac action potential. Lubeluzole can inhibit cancer cells proliferation and invasion and shows chemosensitizing effect. Lubeluzole can be used for the researches of cancer, infection, neurological and cardiovascular disease such as stroke, infectious diarrhea and ovarian .
    Lubeluzole dihydrochloride
  • HY-151589
    HCVcc-IN-2

    		Virus Protease Infection Cancer
    HCVcc-IN-2 is a benzothiazole-2-thiophene S-glycoside derivative with antitumor and antiviral activity. HCVcc-IN-2 has high inhibition against the three cell line from CNS cancer (SF-539 and SNB-75), colon cancer (HCT-116), and renal cancer (A498) .
    HCVcc-IN-2
  • HY-75577
    4-Amino-3-methoxybenzoic acid

    		Drug Intermediate Cancer
    4-Amino-3-methoxybenzoic acid is a drug intermediate that can be used to construct benzothiazole compounds with anti-breast cancer activity .
    4-Amino-3-methoxybenzoic acid
  • HY-108896
    Icatibant acetate
    10+ Cited Publications

    HOE 140 acetate

    		 Bradykinin Receptor Inflammation/Immunology
    Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC50 and Ki of 1.07 nM and 0.798 nM respectively .
    Icatibant acetate
  • HY-124084
    SW203668

    		Drug Derivative Bacterial Cancer
    SW203668 is a benzothiazole compound, shows anti-tumor activity against lung cancer cell lines (IC50=0.022-0.116 μM)
    SW203668
  • HY-124084A
    SW203668 TFA

    		Drug Derivative Bacterial Cancer
    SW203668 TFA is a benzothiazole compound, shows anti-tumor activity against lung cancer cell lines (IC50=0.022-0.116 μM)
    SW203668 TFA
  • HY-D0218
    Thioflavin T
    Maximum Cited Publications
    25 Publications Verification

    Basic Yellow 1

    		 Amyloid-β Others
    Thioflavin T is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections. Excitation max.: ~385 nm (free); ~450 nm (bound); Emission max.: ~445 nm (free); ~485 nm (bound) .
    Thioflavin T
  • HY-Y0425
    Terephthalaldehyde

    Terephthalaldehyde

    		 Drug Intermediate Others
    Terephthalaldehyde is a cross-linking agent. Terephthalaldehyde can copolymerize with chitosan and acrylic acid to form hydrogels that selectively adsorb anionic dyes. Terephthalaldehyde can be used as a drug intermediate to synthesize a series of novel benzothiazole and benzotriazolopyrimidinone heterocyclic compounds .
    Terephthalaldehyde
  • HY-174454
    Antitrypanosomal agent 24

    		P-glycoprotein Infection
    Antitrypanosomal agent 24 is a benzothiazole amidoxime with strong and selective antitrypanosomal activity (IC50 = 0.92 μM). Antitrypanosomal agent 24 is a substrate of the P-glycoprotein efflux pump. Antitrypanosomal agent 24 has high membrane permeability and good metabolic stability. Antitrypanosomal agent 24 binds to DNA/RNA by intercalation .
    Antitrypanosomal agent 24
  • HY-149925
    DNA Gyrase-IN-6

    		Bacterial DNA/RNA Synthesis Topoisomerase Infection
    Antibacterial agent 138 is a benzothiazole inhibitor of bacterial DNA gyrase and topoisomerase IV. Antibacterial agent 138 exhibits favorable solubility and plasma protein binding. Antibacterial agent 138 has antibacterial activity against Gram-positive and Gram-negative strains. Antibacterial agent 138 is a dual GyrB and ParE inhibitor .
    DNA Gyrase-IN-6
  • HY-W176465
    BTA-2

    		Amyloid-β Others
    BTA-2, a benzothiazole dye, is structurally similar to thioflavin T (ThT), which exhibits an enhanced fluorescence signal when bound to amyloid fibrils. BTA-2 has distinct absorption and emission characteristics in solution and when bound to amyloid fibrils, which makes it can used for identifying amyloid fibrils using spectroscopy .
    BTA-2
  • HY-149311
    PPO-IN-2

    		Protoporphyrinogen IX oxidase Others
    PPO-IN-2 is an inhibitor of protoporphyrinogen IX oxidase with an Ki of 16 nM .
    PPO-IN-2
  • HY-W040269
    Dehydrothio-p-toluidine
    1 Publications Verification

    DHPT

    		 Fluorescent Dye Others
    Dehydrothio-p-toluidine (DHPT) is a chemical intermediate used in dyestuff production. Dehydrothio-p-toluidine shows inhalation toxicity in acute and subchronic conditions .
    Dehydrothio-p-toluidine
  • HY-147901
    KDM1/CDK1-IN-1

    		Histone Demethylase CDK Apoptosis Caspase Cancer
    KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, with IC50 values of 16.34, 3.45 and 7.79 μM, respectively .
    KDM1/CDK1-IN-1
  • HY-146239
    EGFR/HER2/TS-IN-2

    		EGFR Thymidylate Synthase Cancer
    EGFR/HER2/TS-IN-2 (compound 17) is a potent EGFR/HER2 and TS (Thymidylate synthase) inhibitor, with IC50 values of 0.173, 0.125, and 1.12 μM, respectively. EGFR/HER2/TS-IN-2 shows cytotoxic activity against MDA-MB-231 cancer cell lines, with an IC50 of 1.69 µM .
    EGFR/HER2/TS-IN-2

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