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BTR2000

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-172563
    BTR2000

    		Ligands for E3 Ligase Others
    BTR2000, a specifically KLHL20 ligand, is capable of binding to the KLHL20 Kelch domain with high affinity. BTR2000 can be used as a ligand for E3 ligase for the synthesis of BTR2004 (HY-172562) .
    BTR2000
  • HY-172564
    BTR2000-Gly-Gly-Gly

    		E3 Ligase Ligand-Linker Conjugates Others
    BTR2000-Gly-Gly-Gly, a E3 ligase ligand-linker conjugate (KLHL20), can be used for the synthesis of PROTAC BTR2004 (HY-172562).
    BTR2000-Gly-Gly-Gly
  • HY-172562
    BTR2004

    		PROTACs Epigenetic Reader Domain Cancer
    BTR2004 is a selective BET family (BRD2/3/4) protein PROTAC degrader. BTR2004 forms a ternary complex with BRD proteins and KLHL20, inducing ubiquitination and proteasomal degradation through the UPS pathway. BTR2004 is promising for research of PC3 prostate cancer and MDA-MB-231 breast cancer cell lines. Pink: (+)-JQ1-OH (HY-161125); Blue: BTR2000 (HY-172563); Black: Linker (HY-W015236) .
    BTR2004

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