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BRD4 degrader-4

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114305
    A1874
    1 Publications Verification

    		 PROTACs Epigenetic Reader Domain Cancer
    A1874 is a nutlin-based (MDM2 ligand) and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation .
    A1874
  • HY-164995
    L1BC8

    		PROTACs Epigenetic Reader Domain Drug-Linker Conjugates for ADC Cancer
    L1BC8 (compound 13a) is a BRD4 PROTAC degrader with anticancer effects. L1BC8 is also a drug-linker conjugate for ADC that can be used for the synthesis of ADCs. The resulting BRD4-degrader antibody conjugates exhibit potent and antigen-dependent BRD4 degradation and antiproliferation activities in cell-based experiments. (Pink: BRD4 ligand (HY-129939); Blue: VHL ligand (HY-125845); Black: linker (HY-171663)) .
    L1BC8
  • HY-160527
    BRD4 degrader-4

    		Epigenetic Reader Domain Cancer
    BRD4 degrader-4 (Compound 1-f) is a BRD4 degrader. BRD4 degrader-4 can be used for the research of cancer and other bromodomain related diseases .
    BRD4 degrader-4

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