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B-hGLP1R knock-in mice

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-173479
    GLP-1R agonist 30

    		GLP Receptor Cardiovascular Disease Metabolic Disease
    GLP-1R agonist 30 is a selective and orally active GLP-1R agonist with an EC50 of 0.048 nM. GLP-1R has excellent selectivity, with EC50 greater than 20 μM for GLP-2R, GIPR, and GCPR. GLP-1R agonist significantly increases cAMP-stimulating activity while markedly reducing hERG inhibitory activities. GLP-1R agonist has preferable absorption and excellent β-arrestin pathway selectivity. GLP-1R agonist effectively improves glucose tolerance and promoted insulin secretion in B-hGLP1R knock-in mice .
    GLP-1R agonist 30

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