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Results for "

Axin2

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Inhibitory Antibodies

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-123851
    MSC2504877

    M2912

    		 PARP Cancer
    MSC2504877 (M2912) is a potent and orally active tankyrase inhibitor with IC50s of 0.0007, 0.0008, 0.54 µM for TNKS, TNKS2, PARP1, respectively. MSC2504877 increases the expression of AXIN2 and TNKS protein levels and decreases β-catenin levels. MSC2504877 shows anti-tumor activity .
    MSC2504877
  • HY-112799
    DK419

    		Wnt β-catenin c-Myc CDK Survivin Cancer
    DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK .
    DK419
  • HY-163767
    Antitumor agent-171

    		β-catenin Inflammation/Immunology Cancer
    Antitumor agent-171 (Compound 35) is an inhibitor for β-catenin/BCL9 interaction with IC50 of 1.61 μM. Antitumor agent-171 exhibits high affinity to β-catenin with Kd of 0.63 μM. Antitumor agent-171 inhibits the gene expression of axin2 with IC50 of 0.84 μM. Antitumor agent-171 inhibits cell viability of HCT116 with IC50 of 4.39 μM. Antitumor agent-171 activates T cells, promotes antigen presentation, and exhibits antitumor efficacy and good pharmacokinetic characteristics in mouse models .
    Antitumor agent-171
  • HY-RS01292
    AXIN2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    AXIN2 Human Pre-designed siRNA Set A contains three designed siRNAs for AXIN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AXIN2 Human Pre-designed siRNA Set A
    AXIN2 Human Pre-designed siRNA Set A
  • HY-RS27378
    Axin2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Axin2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Axin2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Axin2 Rat Pre-designed siRNA Set A
    Axin2 Rat Pre-designed siRNA Set A
  • HY-RS20863
    Axin2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Axin2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Axin2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Axin2 Mouse Pre-designed siRNA Set A
    Axin2 Mouse Pre-designed siRNA Set A
  • HY-108516
    TC-E 5001

    		Wnt PARP Cancer
    TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively [2].
    TC-E 5001
  • HY-P991311
    GSK3178022

    		LPL Receptor Wnt Cancer
    GSK3178022 is a human IgG1 monoclonal antibody (mAb) targeting LRP6. GSK3178022 inhibits the expression of WNT target genes SP5 and AXIN2. GSK3178022 has antitumor activity in the RSPO fusion model of colorectal cancer. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
    GSK3178022
  • HY-148918
    E722-2648

    		β-catenin Wnt Cancer
    E722-2648 is a potent β-catenin/BCL9 complex inhibitor. E722-2648 specifically inhibits β-catenin/BCL9 complex formation and Wnt activity. E722-2648 disrupts cholesterol homeostasis via increased cholesterol esterification and lipid droplet accumulation. E722-2648 has antitumor activity .
    E722-2648

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