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Results for "

Axin-1

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

1

Peptides

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-141543
    YW2065

    		β-catenin Cancer
    YW2065 is an Axin-1 stabilizer. Axin-1 is a scaffolding protein that regulates proteasome degradation of β-catenin. YW2065 exhibits anti-colorectal cancer effects via dual activities of wnt/β-catenin signaling inhibition and AMPK activation [1].
    YW2065
  • HY-147245
    Basroparib

    STP1002

    		 PARP Cancer
    Basroparib (STP1002) is a selective, orally active inhibitor of tankyrase (TNKS1/TNKS2) with IC50 of 29.94 nM and 3.68 nM for TNKS1 and TNKS2, respectively. Basroparib has an IC50 of >10 μM for PARP1. Basroparib binds to TNKS, stabilizes AXIN1/2 proteins, blocks Wnt/β-catenin signaling pathway, inhibits tumor cell proliferation and induces apoptosis, while reducing cancer stem cell properties. Basroparib can be used in colorectal cancer (CRC) studies with KRAS mutations (such as G12V/G12D) to overcome acquired resistance to MEK inhibitors. STP1002 has synergistic antitumor activity with MEK inhibitors [1] .
    Basroparib
  • HY-RS01291
    AXIN1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    AXIN1 Human Pre-designed siRNA Set A contains three designed siRNAs for AXIN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AXIN1 Human Pre-designed siRNA Set A
    AXIN1 Human Pre-designed siRNA Set A
  • HY-RS28926
    Axin1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    Axin1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Axin1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Axin1 Rat Pre-designed siRNA Set A
    Axin1 Rat Pre-designed siRNA Set A
  • HY-RS22402
    Axin1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Axin1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Axin1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Axin1 Mouse Pre-designed siRNA Set A
    Axin1 Mouse Pre-designed siRNA Set A
  • HY-173349
    TDI-012804

    		PARP Cancer
    TDI-012804 is a TNKS2 inhibitor that selectively inhibits intracellular endogenous TNKS2 protein. TDI-012804 increases the expression of AXIN1 protein in cells that are heterozygous (Tnks1HET) and completely knocks out (Tnks1KO) for TNKS1. TDI-012804 inhibits the proliferation of ApcQ1405X/Tnks1KO organoids (EC50 of 59.1 nM) and is selectively toxic to Tnks1KO AKP-G12D and AKP-G13D organoids [1].
    TDI-012804
  • HY-107528
    FRATtide

    		β-catenin GSK-3 Cancer
    FRATtide is a peptide derived from the GSK-3 binding protein that inhibits the phosphorylation of Axin and β-catenin. FRATtide inhibits GSK-3 binding to Axin .
    FRATtide

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