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Aurora-A kinase

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By Targets:	Aurora Kinase (8) Apoptosis (3) Bcr-Abl (1) c-Myc (1) CDK (1) EGFR (1) FLT3 (1) G Protein-coupled Receptor Kinase (GRK) (1) Histone Methyltransferase (1) Mitosis (1) PROTACs (1) TAM Receptor (1) Tie (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (1)

9

Inhibitors & Agonists

1

Natural
Products

1

Recombinant Proteins

2

Antibodies

Targets Recommended: Aurora Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Phthalazinone pyrazole	Aurora Kinase Apoptosis Mitosis	Cancer
Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC₅₀ of 0.031 μM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells .

JB170 2 Publications Verification	PROTACs Aurora Kinase	Cancer
JB170 is a potent and highly specific PROTAC-mediated *AURORA-A* (Aurora *Kinase) degrader (DC₅₀=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A* (EC₅₀=193 nM) over AURORA-B (EC₅₀=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase .

LY3295668 2 Publications Verification AK-01	Aurora Kinase	Cancer
LY3295668 (AK-01) is a potent, orally active and highly specific **Aurora-A kinase inhibitor, with K_i** values of 0.8 nM and 1038 nM for AurA and AurB, respectively.

JNJ-7706621 4 Publications Verification	Aurora Kinase CDK Apoptosis	Cancer
JNJ-7706621 is a potent **aurora kinase inhibitor, and also inhibits CDK1 and CDK2, with IC₅₀s of 9 nM, 3 nM, 11 nM, and 15 nM for CDK1, CDK2, aurora-A and aurora-B**, respectively .

CCT241736	FLT3 Aurora Kinase	Cancer
CCT241736 is a potent and orally bioavailable dual FLT3 and **Aurora kinase** inhibitor, which inhibits Aurora kinases (Aurora-A K_d, 7.5 nM, IC₅₀, 38 nM; Aurora-B K_d, 48 nM), FLT3 kinase (K_d, 6.2 nM), and FLT3 mutants including FLT3-ITD (K_d, 38 nM) and FLT3(D835Y) (K_d, 14 nM).

GRK2 Inhibitor 2	Aurora Kinase G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease
GRK2 Inhibitor 2 is an orally active and selective G protein-coupled receptor kinase 2 (GRK) inhibitor with an IC₅₀ of 19 nM. GRK2 Inhibitor 2 also inhibits *Aurora-A* with an IC₅₀ of 137 nM. GRK2 Inhibitor 2 can be used in the study of congestive heart failure (HF) .

Aurora A inhibitor 3	Aurora Kinase	Cancer
Aurora A inhibitor 3 (Compound 5h) inhibits Aurora-A kinase with an IC₅₀ value of 0.78 μM. Aurora A inhibitor 3 is cytotoxic, with GI₅₀ values of 0.12 μM and 0.63 μM for MCF-7 and MDA-MB-231 cells, respectively .

Corylifol C	EGFR TAM Receptor Tie	Cancer
Corylifol C is a potent protein kinase inhibitor with IC₅₀ valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively .

PHA-680626	Aurora Kinase c-Myc Bcr-Abl Histone Methyltransferase Apoptosis	Cancer
PHA-680626 is an effective inhibitor of the interaction between *Aurora-A* and N-Myc. PHA-680626 inhibits kinase activity of AURKA and Bcr-Abl, and induces N-Myc degradation. PHA-680626 decreases phosphorylation of CrkL and histone H3. PHA-680626 shows anti-proliferative and pro-apoptotic activity on Imatinib (HY-15463)-resistant chronic myeloid leukemia cell lines and primary CD34+ cells .

Cat. No.	Compare	Product Name	Species	Source

	AURA Protein, Human (sf9) AURKA; Aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase Aurora-A	Human	Sf9 insect cells
	AURA is a mitotic serine/threonine kinase that complexly controls cell cycle progression and various mitotic events. AURA associates with centrosomes and spindle microtubules during mitosis and plays a critical role in spindle establishment, centrosome duplication, chromosome alignment, spindle assembly checkpoint activation, and cytokinesis. AURA Protein, Human (sf9) is the recombinant human-derived AURA protein, expressed by sf9 insect cells , with tag free.

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	Aurora A Antibody (YA6333) Aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase Aurora-A;	WB, IHC-P, ICC/IF, IP, ELISA	Human
	Aurora A Antibody (YA6333) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aurora A.

	Aurora A Antibody (YA827) AIK; ARK1; AYK1; Aurora-A; Aurora-related kinase 1; BTAK; IAK1; Ipl1- and Aurora-related kinase 1; STK15; STK6; Serine/threonine kinase 15	WB, ICC/IF	Human, Monkey
	Aurora A Antibody (YA827) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Aurora A.

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