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Isoforms Recommended: IDO1
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Apo-IDO1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111540
    LY-3381916
    2 Publications Verification

    IDO1-IN-5

    		 Indoleamine 2,3-Dioxygenase (IDO) Cancer
    LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 [1].
    LY-3381916
  • HY-111540A
    (Rac)-LY-3381916

    (Rac)-IDO1-IN-5

    		 Indoleamine 2,3-Dioxygenase (IDO) Cancer
    (Rac)-LY-3381916 ((Rac)-IDO1-IN-5; Example 1) is a racemate of LY-3381916 [1]. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .
    (Rac)-LY-3381916
  • HY-111540B
    (S)-LY-3381916
    1 Publications Verification

    (S)-IDO1-IN-5

    		 Indoleamine 2,3-Dioxygenase (IDO) Cancer
    (S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ [1]. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .
    (S)-LY-3381916
  • HY-178011
    IDO1-IN-28

    		Indoleamine 2,3-Dioxygenase (IDO) Cancer
    IDO1-IN-28 (Compound MQ-1) is a Apo-IDO1 inhibitor with an IC50 of 1.29  μM. IDO1-IN-28 selectively targets apo-IDO1 and disrupts heme binding. IDO1-IN-28 can be used for cancers research [1].
    IDO1-IN-28
  • HY-178024
    IDO1-IN-29

    		Indoleamine 2,3-Dioxygenase (IDO) Cancer
    IDO1-IN-29 (Compound MQ-1n) is a Apo-IDO1 inhibitor with an IC50 of 0.29  μM. IDO1-IN-29 selectively targets apo-IDO1 and disrupts heme binding. IDO1-IN-29 can be used for cancers research [1].
    IDO1-IN-29
  • HY-172453
    XW-032

    		Indoleamine 2,3-Dioxygenase (IDO) Cancer
    XW-032 is an apo-IDO1 inhibitor, with an IC50 of 21 nM. XW-032 (TGI = 63%) exhibits potent in vivo anti-tumor efficacy in the CT26 syngeneic mouse model and is expected to be applied in the research of the field of cancer [1].
    XW-032

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