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Results for "

Adamantyl

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101867
    AU1235
    2 Publications Verification

    		 Bacterial Infection Cancer
    AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane .
    AU1235
  • HY-103275
    Adaphostin

    NSC 680410

    		 Bcr-Abl Apoptosis Cancer
    Adaphostin (NSC 680410), the adamantyl ester of AG957, is a potent p210 bcr/abl inhibitor (IC50=14 μM). Adaphostin induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 ranging from 17 to 216 nM). Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Adaphostin increased the level of reactive oxygen species (ROS) within CLL B cells .
    Adaphostin
  • HY-W751667
    1-Adamantyl Methyl Ketoxime-d3

    		Isotope-Labeled Compounds Others
    1-Adamantyl Methyl Ketoxime-d3 is the deuterium labeled 1-Adamantyl Methyl Ketoxime (HY-W751666).
    1-Adamantyl Methyl Ketoxime-d3
  • HY-167919
    1-(1-Adamantyl)-3-butyl-2-thiourea

    		Drug Derivative Infection
    1-(1-Adamantyl)-3-butyl-2-thiourea is a compound with antiviral activity, demonstrating efficacy against various viral pathogens; 1-(1-Adamantyl)-3-butyl-2-thiourea serves as a potential therapeutic agent in the treatment of viral infections.
    1-(1-Adamantyl)-3-butyl-2-thiourea
  • HY-W338244
    2-Amino-4-(1-adamantyl)thiazole

    		Drug Intermediate Others
    2-Amino-4-(1-adamantyl)thiazole is a synthetic intermediate useful for pharmaceutical synthesis.
    2-Amino-4-(1-adamantyl)thiazole
  • HY-114747
    1-(Adamantan-1-yl)-3-propylthiourea

    1-(1-Adamantyl)-3-propyl-2-thiourea

    		 Others Infection
    1-(Adamantan-1-yl)-3-propylthiourea (1-(1-Adamantyl)-3-propyl-2-thiourea) is a viricide .
    1-(Adamantan-1-yl)-3-propylthiourea
  • HY-14988
    I-A09

    		Bacterial Infection
    I-A09 and its derivatives, specifically 1,2,3-triazole-adamantylacetamide hybrids (5a–u), exhibit significant antitubercular activity. These hybrids were synthesized using copper-catalyzed click chemistry, combining bioactive fragments from antitubercular I-A09 and substituted adamantyl urea. The compound N-(1-adamantyl)-2-azido acetamide was reacted with various alkyl/aryl acetylenes to produce new analogues. Among them, N-(1-adamantan-1-yl)-2-(4-(phenanthren-2-yl)-1H-1,2,3-triazol-1-yl)acetamide (5t) showed the most promise with a minimum inhibitory concentration (MIC) of 3.12 μg/mL against Mycobacterium tuberculosis H37Rv, and a selectivity index greater than 15 .
    I-A09
  • HY-149730
    ICMT-IN-54

    		ICMT Cancer
    ICMT-IN-54 (compound 7c) is an adamantyl analogue and an ICMT inhibitor (IC50=12.4 μM), which can inhibit ICMT Methylation. ICMT-in-54 inhibits BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) methylation in saccharomyces cerevisiae expressing ICMT, which is an indirect effect of inhibiting ICMT methylation .
    ICMT-IN-54
  • HY-103275R
    Adaphostin (Standard)

    NSC 680410 (Standard)

    		 Reference Standards Bcr-Abl Apoptosis Cancer
    Adaphostin (Standard) is the analytical standard of Adaphostin. This product is intended for research and analytical applications. Adaphostin (NSC 680410), the adamantyl ester of AG957, is a potent p210bcr/abl inhibitor (IC50=14 μM). Adaphostin induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 ranging from 17 to 216 nM). Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Adaphostin increased the level of reactive oxygen species (ROS) within CLL B cells .
    Adaphostin (Standard)
  • HY-150543
    Steroid sulfatase-IN-3

    		Steroid Sulfatase Cancer
    Steroid sulfatase-IN-3 (compound 1q) is a potent STS (Steroid sulfatase) inhibitor, with an IC50 of 25.8 nM. Steroid sulfatase-IN-3 shows antiproliferative activity against T-47D estrogen-dependent breast cancer cells, with an IC50 of 1.04 µM .
    Steroid sulfatase-IN-3

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