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Results for "

Acute Pancreatitis model

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

3

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0469R
    L-Lysine (Standard)

    		Reference Standards Endogenous Metabolite Virus Protease HSV Infection Metabolic Disease Inflammation/Immunology
    L-Lysine (Standard) is the analytical standard of L-Lysine. This product is intended for research and analytical applications. L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of HSV infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation . IC50 & Target:L-lysine (150 mg/kg) promotes, but not initiates, bladder cancer. The administration of L-lysine to rats submitted to colovesical cystoplasty accelerates the development of transitional metaplasia of the intestinal epithelium .
    L-lysine (10 mg/kg) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity . In Vivo:L-lysine (10?mg/kg, p.o., pre-treated or post-treated, administration duration 15 days) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity in acute pancreatitis mice model . L-lysine (5 or 10?mg/kg, p.o., 45 days) ameliorates sepsis-induced acute lung injury in a lipopolysaccharide (HY-D1056)-induced mouse model .
    L-Lysine (Standard)
  • HY-N0469
    L-Lysine
    Maximum Cited Publications
    6 Publications Verification

    		 Endogenous Metabolite Virus Protease HSV Infection Metabolic Disease Inflammation/Immunology
    L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of HSV infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation .
    L-Lysine
  • HY-B2123
    Lactose
    2 Publications Verification

    		 Endogenous Metabolite Interleukin Related ERK NF-κB Inflammation/Immunology
    Lactose is a β-galactoside consisting of galactose and glucose residues，the main carbohydrate in mammalian breast milk. Lactose，a macronutrient and an inducer of host innate immune responses，possesses immune modulatory functions .
    Lactose
  • HY-168211
    LQ-38

    		Epoxide Hydrolase Inflammation/Immunology
    LQ-38 is an orally active inhibitor for soluble epoxide hydrolase (sEH) with an IC50 of 5.2 nM. LQ-38 exhibits anti-inflammatory activity in rat foot edema model and mouse acute pancreatitis model, exhibits analgesic effect in Acetic acid (HY-Y0319)-induced writhing mouse model .
    LQ-38
  • HY-N0469A
    L-Lysine (sulfite)

    		Endogenous Metabolite Virus Protease Inflammation/Immunology Cancer
    L-lysine sulfite is an essential amino acid for humans , offers numerous benefits and can be used in herpes research. Additionally, L-lysine sulfite enhances calcium absorption, reduces diabetes-related complications, improves gut health, and alleviates pancreatitis inflammation .
    L-Lysine (sulfite)
  • HY-170492
    sEH inhibitor-19

    		Epoxide Hydrolase Interleukin Related TNF Receptor Inflammation/Immunology
    sEH inhibitor-19 (Compound (R)-14i) is an orally active inhibitor for soluble epoxide hydrolase (sEH) with an IC50 of 1.2 nM. sEH inhibitor-19 inhibits the expression of TNF-α and IL-6, exhibits anti-inflammatory activity in mouse acute pancreatitis or Carrageenan (HY-125474)-induced edema models .
    sEH inhibitor-19
  • HY-174802
    XL-3158

    		Cyclic GMP-AMP Synthase IKK IFNAR Inflammation/Immunology
    XL-3158 is a selective and cross-species Cyclic GMP-AMP synthase (cGAS) inhibitor (IC50: 11.1 μM for human cGAS, 2.19 μM for mouse cGAS). XL-3158 simultaneously occupy allosteric and orthosteric sites, stabilizing the activation loop in a closed, inactive conformation and thereby attenuating the cGAS-DNA interactions. XL-3158 inhibits cGAS by targeting phase separation. XL-3158 efficiently penetrates cells by inhibiting aggregate formation, effectively reducing the local concentration of cGAS within cells. XL-3158 has no obvious cytotoxicity within the effective concentration range and is suitable for subsequent cell function experiments. XL-3158 overcomes species selectivity barriers and serves as a drug candidate for cGAS-dependent inflammatory diseases[1].
    XL-3158

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