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AY 4

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-174867
    AY-4

    		PROTACs Ferroptosis Cancer
    AY-4 (Compound AY-4) is an efficient PROTAC degrader targeting FTH1 (Kd = 3.17 nM). AY-4 effectively upregulates the levels of ferrous (Fe 2+) and ferric (Fe 3+) ions in cells. AY-4 is a potential anticancer candidate compound that regulates iron homeostasis through ferritin degradation and enhances the efficacy of existing drugs. AY-4 can effectively reduce the level of FTH1 in breast cancer cells (Pink: FTH1 ligand AY-2 (HY-174871); Blue: E3 ligand Pomalidomide (HY-10984); Black: Linker, Pomalidomide-PEG3-acid (HY-174872)) .
    AY-4
  • HY-174871
    AY-2

    		Ligands for Target Protein for PROTAC Cancer
    AY-2 is a binding ligand for FTH1 and can be used to synthesize PROTACs such as AY-4 (HY-174867) .
    AY-2
  • HY-174872
    Pomalidomide-PEG3-acid

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Pomalidomide-PEG3-acid is a synthetic E3 ubiquitin ligase ligand-linker conjugate that can be used to synthesize PROTACs such as AY-4 (HY-174867) .
    Pomalidomide-PEG3-acid

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