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ASPT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Huntingtin (1) Transthyretin (TTR) (1)
By Research Areas:	Cardiovascular Disease (1) Neurological Disease (3)
Oligonucleotides:	Antisense Oligonucleotides (4)

5

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Natural
Products

4

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Tofersen BIIB067; ISIS-SOD1Rx	DNA/RNA Synthesis	Neurological Disease
Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS) .

*ASPT*	Biochemical Assay Reagents	Others
ASPT is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Tominersen RG6042; IONIS-HTTRx	Huntingtin	Neurological Disease
Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD) .

Tonlamarsen ION-904	Endogenous Metabolite	Cardiovascular Disease
Tonlamarsen is a angiotensinogen synthesis reducer, with antihypertensive activity .

Eplontersen	Transthyretin (TTR)	Neurological Disease
Eplontersen is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

Cat. No.	Product Name		Classification

Tofersen BIIB067; ISIS-SOD1Rx		Antisense Oligonucleotides
Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS) .

Tominersen RG6042; IONIS-HTTRx		Antisense Oligonucleotides
Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen improves survival and reduces brain atrophy in mice. Tominersen can be used for the research of Huntington’s disease (HD) .

Tonlamarsen ION-904		Antisense Oligonucleotides
Tonlamarsen is a angiotensinogen synthesis reducer, with antihypertensive activity .

Eplontersen		Antisense Oligonucleotides
Eplontersen is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

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