APs

By Targets:	Apoptosis (1) Biochemical Assay Reagents (1) Drug Intermediate (1) ERK (1) GABA Receptor (1) MEK (2) nAChR (1) Phosphatase (1) Ras (1) RET (1) Small Interfering RNA (siRNA) (3) Wnt (1)
By Research Areas:	Cancer (5) Infection (1) Metabolic Disease (1)
Oligonucleotides:	Nucleotide Analogs (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) Adenine Nucleotide (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124944

APS6-45	Ras	Cancer
APS6-45 is an orally active tumor-calibrated inhibitor (TCI). APS6-45 inhibits RAS/MAPK signaling and exhibits antitumor activity .

HY-100627

APS-2-79	MEK	Cancer
APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATP ^biotin binding to KSR2 within the KSR2-MEK1 complexe with an IC₅₀ of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling .

HY-160765

WNTinib APs-8-100-2	Wnt Apoptosis	Cancer
WNTinib (APS-8-100-2) is a multi-kinase inhibitor that selectively antagonizes β-catenin (CTNNB1) mutated hepatocellular carcinoma (HCC). WNTinib downregulates oncogenicWntsignaling by inhibiting KIT/MAPK and downstream EZH2 activation .

HY-112832

*Lumigen APS-5*	Phosphatase	Infection
Lumigen APS-5 is a substrate of alkaline phosphatase (ALP). Lumigen APS-5 can be used to assess the activity of alkaline phosphatase (ALP) .

HY-137528

H-Glu(4MβNA)-OH H-Glu(4MbetaNA)-OH; L-Glutamic acid γ-(4-methoxy-β-naphthylamide)	Others	Others
H-Glu(4MβNA)-OH is a substrate of aminopeptidases (APs) .

HY-100627A

APS-2-79 hydrochloride	MEK	Cancer
APS-2-79 hydrochloride is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATP ^biotin binding to KSR2 within the KSR2-MEK1 complexe with an IC₅₀ of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling .

HY-178061

APS03118	ERK RET	Cancer
APS03118 is an orally active, potent and selective rearranged during transfection (RET) inhibitor. APS03118 broadly inhibits RET fusions and mutations (including G810, V804, L730, and Y806 variants), with IC₅₀ values predominantly below 1 nM (0.095 nM for WT; ranging from 0.00438 to 5.72 nM for mutants), and demonstrates marked superiority against RET G810 mutations. APS03118 inhibits the entire RET signaling pathway (including RET, Shc, and ERK1/2), with >20-fold selectivity over most off-target kinases (except FLT3 and YES). APS03118 induces complete tumor regression in KIF5B-RET and CCDC6-RET V804 M patient derived xenografts (PDXs) and significantly prolongs survival in an intracranial CCDC6-RET metastasis mice model. APS03118 can be used for selective RET inhibitor (SRI)-resistant, RET-driven cancer research .

HY-155381

APS3	GABA Receptor nAChR	Others
APS3 is a GABA and nACh receptors inhibitor, with a LC₅₀ of 7.2423 μg/mL against Plutella xylostella .

HY-RS12819

SH2B2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SH2B2 Human Pre-designed siRNA Set A contains three designed siRNAs for SH2B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SH2B2 Human Pre-designed siRNA Set A SH2B2 Human Pre-designed siRNA Set A

HY-E70606

ATP sulfase, yeast	Biochemical Assay Reagents	Others
ATP sulfase, yeast is an ATP sulfatase. ATP sulfase, yeast catalyzes the activation of sulfate by transferring sulfate to the adenine monophosphate group of ATP to form adenosine-5'-phosphosulfate (APS) and pyrophosphate (PPi).

HY-113606

Adenosine 5'-phosphosulfate disodium	Drug Intermediate	Metabolic Disease
Adenosine 5'-phosphosulfate disodium is a metabolism intermediates of sulfur. Adenosine 5'-phosphosulfate disodium can used in study sulfotransferases and sulforeductases in various organisms .

HY-RS07381

KLK3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KLK3 Human Pre-designed siRNA Set A contains three designed siRNAs for KLK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KLK3 Human Pre-designed siRNA Set A KLK3 Human Pre-designed siRNA Set A

HY-RS17665

Klkb1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Klkb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Klkb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Klkb1 Mouse Pre-designed siRNA Set A Klkb1 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-112832

*Lumigen APS-5*	Enzyme Substrates
Lumigen APS-5 is a substrate of alkaline phosphatase (ALP). Lumigen APS-5 can be used to assess the activity of alkaline phosphatase (ALP) .

Species:	Human (2)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70606

	Kallikrein-3/PSA Protein, Human (237a.a, HEK293, His) Prostate-specific antigen; PSA; Gamma-seminoprotein; Kallikrein-3; P-30 antigen; Semenogelase; KLK3; APs	Human	HEK293
	Kallikrein-3 (PSA) protein, pivotal in the male reproductive system, hydrolyzes semenogelin-1, a seminal vesicle protein. This enzymatic activity initiates seminal coagulum liquefaction, crucial for sperm mobility and fertility. PSA's cleavage of semenogelin-1 highlights its importance in the complex processes of semen physiology and male reproductive function. Kallikrein-3/PSA Protein, Human (237a.a, HEK293, His) is the recombinant human-derived Kallikrein-3/PSA protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70266

	Kallikrein-3/PSA Protein, Human (244a.a, HEK293, His) 1 Publications Verification rHuProstate-specific antigen/KLK3, His; Prostate-Specific Antigen; PSA; Gamma-Seminoprotein; Seminin; Kallikrein-3; P-30 Antigen; Semenogelase; KLK3; APs	Human	HEK293
	Kallikrein-3 (PSA) protein, pivotal in the male reproductive system, hydrolyzes semenogelin-1, a seminal vesicle protein. This enzymatic activity initiates seminal coagulum liquefaction, crucial for sperm mobility and fertility. PSA's cleavage of semenogelin-1 highlights its importance in the complex processes of semen physiology and male reproductive function. Kallikrein-3/PSA Protein, Human (244a.a, HEK293, His) is the recombinant human-derived Kallikrein-3/PSA protein, expressed by HEK293 , with C-His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81792

	Prostate Specific Antigen Antibody (YA1537) KLK3; APs; Prostate-specific antigen; PSA; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase	WB, IHC-P	Human
	Prostate Specific Antigen Antibody (YA1537) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Prostate Specific Antigen.

HY-P83800

	SH2B2 Antibody (YA3497) APs	IHC-P, FC, ELISA	Human
	SH2B2 Antibody (YA3497) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to SH2B2.

HY-P83986

	Prostate Specific Antigen Antibody (YA3683) APs; PSA; hK3; KLK2A1; KLK3	IHC-P, FC, ELISA	Human
	Prostate Specific Antigen Antibody (YA3683) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Prostate Specific Antigen.

HY-P85338

	Prostate Specific Antigen Antibody (YA5030) KLK3; APs; Prostate-specific antigen; PSA; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase	IHC-P; IHC-F; IF; ELISA	Human
	Prostate Specific Antigen Antibody (YA5030) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Prostate Specific Antigen.

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Cat. No.	Product Name		Classification

HY-113606

Adenosine 5'-phosphosulfate disodium		Nucleotide Analogs Adenine Nucleotide
Adenosine 5'-phosphosulfate disodium is a metabolism intermediates of sulfur. Adenosine 5'-phosphosulfate disodium can used in study sulfotransferases and sulforeductases in various organisms .

HY-RS12819

SH2B2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SH2B2 Human Pre-designed siRNA Set A contains three designed siRNAs for SH2B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07381

KLK3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
KLK3 Human Pre-designed siRNA Set A contains three designed siRNAs for KLK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17665

Klkb1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Klkb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Klkb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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