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Results for "

ALC-0315

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

2

Biochemical Assay Reagents

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-138170
    ALC-0315
    20+ Cited Publications

    		 Liposome SARS-CoV Infection
    ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .
    ALC-0315
  • HY-138170A
    ALC-0315 (Excipient, GMP Like)

    		Liposome SARS-CoV Infection
    ALC-0315 (Excipient, GMP Like) is the GMP Like class ALC-0315 (HY-138170), and can be used as pharmaceutical excipients. ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 (Excipient, GMP Like) can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .
    ALC-0315 (Excipient, GMP Like)
  • HY-142977
    6-Oxohexyl 2-hexyldecanoate, 80% (ELSD)

    		Liposome Drug Intermediate Others
    6-Oxohexyl 2-hexyldecanoate, 80% (ELSD) is an intermediate in the synthesis of ALC-0315. ALC-0315 is an ionizable amino lipid. ALC-0315 is a key component of LNP delivery vehicles. 6-Oxohexyl 2-hexyldecanoate, 80% (ELSD) is an effective delivery vehicle of mRNA .
    6-Oxohexyl 2-hexyldecanoate, 80% (ELSD)
  • HY-173292
    ALC-0315 analogue-4

    		Biochemical Assay Reagents Others
    ALC-0315 analogue-4 is an ALC-0315 analog used in drug delivery.
    ALC-0315 analogue-4
  • HY-172329
    Q1-ALC-0315 iodide

    		Liposome Others
    Q1-ALC-0315 iodide is a cationic quaternary ammonium lipid derivative of the ionizable cationic lipid ALC-0315 (HY-138170). Q1-ALC-0315-based LNPs can be used for lung-targeted mRNA delivery, which demonstrates high-performing firefly luciferase protein expression in the lungs .
    Q1-ALC-0315 iodide
  • HY-W800777
    6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate

    		Liposome Cancer
    6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate is an ionizable lipid which can be used to make ALC-0315. The lipid has an ester bond adjacent to C6 relative to the amine nitrogen. The introduction of ester linkages can improve the clearance of the lipid in the liver.
    6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate
  • HY-172332
    H1L1A1B3

    		Liposome NF-κB Inflammation/Immunology Cancer
    H1L1A1B3 is an ionizable cationic lipid used in the formation of lipid nanoparticles (LNPs) for the delivery of circular RNA (circRNA). H1L1A1B3-LNPs demonstrates a fourfold increase in circRNA transfection efficiency in lung cancer cells over ALC-0315 (HY-138170). H1L1A1B3 can activate the NF-κB/IRF immune pathways .
    H1L1A1B3

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