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5-HT (5-hydroxytryptamine)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (58) Adrenergic Receptor (3) Biochemical Assay Reagents (1) COMT (7) COX (2) Dopamine Receptor (8) Drug Isomer (1) Endogenous Metabolite (8) Fluorescent Dye (1) IFNAR (2) Interleukin Related (2) Isotope-Labeled Compounds (7) Monoamine Oxidase (1) Reactive Oxygen Species (ROS) (2) Reference Standards (3) Serotonin Transporter (4) TNF Receptor (1) Transthyretin (TTR) (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (3) Endocrinology (1) Inflammation/Immunology (5) Metabolic Disease (6) Neurological Disease (46)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: 5-HT Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1473

Serotonin hydrochloride Maximum Cited Publications 15 Publications Verification 5-Hydroxytryptamine hydrochloride; 5-HT hydrochloride	5-HT Receptor COMT Endogenous Metabolite	Neurological Disease
Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM.

HY-B1473A

Serotonin Maximum Cited Publications 15 Publications Verification 5-Hydroxytryptamine; 5-HT	5-HT Receptor COMT Endogenous Metabolite	Neurological Disease
Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM.

HY-B1473S

Serotonin-d4 hydrochloride 5-Hydroxytryptamine-d₄ hydrochloride; 5-HT-d₄ hydrochloride	Isotope-Labeled Compounds 5-HT Receptor Endogenous Metabolite COMT	Others
Serotonin-d₄ (5-Hydroxytryptamine-d₄) hydrochloride is the deuterium labeled Serotonin (hydrochloride) (HY-B1473) . Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

HY-19358

2-Methyl-5-HT 2-Methyl-5-hydroxytryptamine; 2-Methylserotonin; 2-Me-5-HT	5-HT Receptor	Neurological Disease
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT₃ receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects .

HY-N0122

5-Hydroxytryptophan 1 Publications Verification 5-HTP; DL-5-Hydroxytryptophan	Endogenous Metabolite 5-HT Receptor	Neurological Disease Metabolic Disease
5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .

HY-169611

Serotonin maleate 5-Hydroxytryptamine maleate; 5-HT maleate	5-HT Receptor COMT	Neurological Disease
Serotonin hydrogen maleate is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrogen maleate is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

HY-103134

SB 204070A	5-HT Receptor	Inflammation/Immunology
5-HT4 antagonist 3 hydrochloride is a highly selective 5-hydroxytryptamine receptor (5-HT₄) antagonist. 5-HT4 antagonist 3 (hydrochloride) blocks muscarine receptors and sodium channels. 5-HT4 antagonist 3 (hydrochloride) can be used to evaluate function of 5-HT₄ receptor .

HY-129444

MD 780236 free base	Monoamine Oxidase	Cancer
MD 780236 free base is a substrate and selective inhibitor of monoamine oxidase B (MAO-B), competitive with phenylethylamine and 5-hydroxytryptamine (5-HT) .

HY-103139

Altanserin hydrochloride	5-HT Receptor	Metabolic Disease
Altanserin is a 5-hydroxytryptamine (5-HT_2A ) selective radioligand. Altanserin delivers human serotonin. Altanserin can be used to study the biochemical and cellular mechanisms of vulnerability to extracellular 5-HT increase .

HY-19358A

2-Methyl-5-HT hydrochloride 2-Methyl-5-hydroxytryptamine hydrochloride; 2-Methylserotonin hydrochloride; 2-Me-HT hydrochloride	5-HT Receptor	Neurological Disease
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT₃ receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects .

HY-19358B

2-Methyl-5-HT maleate 2-Methyl-5-hydroxytryptamine maleate; 2-Methylserotonin maleate; 2-Me-HT maleate	5-HT Receptor	Neurological Disease
2-Methyl-5-HT maleate (2-Methyl-5-hydroxytryptamine maleate) is a potent and selective 5-HT₃ receptor agonist. 2-Methyl-5-HT maleate is shown to display anti-depressive-like effects .

HY-B1473S2

Serotonin-13C,D4 5-Hydroxytryptamine-¹³C,D₄; 5-HT-¹³C,D₄	Isotope-Labeled Compounds 5-HT Receptor COMT Endogenous Metabolite	Neurological Disease
Serotonin- ¹³C,D₄ (5-Hydroxytryptamine-13C,D₄) is a ¹³C- and deuterated labeled Serotonin (HY-B1473A). Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

HY-N0122R

5-Hydroxytryptophan (Standard)	Endogenous Metabolite 5-HT Receptor	Neurological Disease Metabolic Disease
5-Hydroxytryptophan (Standard) is the analytical standard of 5-Hydroxytryptophan. This product is intended for research and analytical applications. 5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .

HY-59302

Indole-5-carboxylic acid, 98%	Biochemical Assay Reagents	Others
Indole-5-carboxylic acid, 98% is an oxytocin that interacts with serotonin receptors and gamma-aminobutyric acid (GABA) receptors. It has also been reported to interact with various enzymes such as cyclooxygenase-2 (COX-2) and 5-hydroxytryptamine (5-HT) receptors.

HY-10351

Robalzotan NAD-299	5-HT Receptor	Neurological Disease
Robalzotan (NAD-299) is a potent and selective **5-Hydroxytryptamine 1A (5-HT1A)** inhibitor. Robalzotan increases the firing rate of 5-HT cells. Robalzotan induces 5-HT1A receptor occupancy. Robalzotan has the potential for the research of a cholinergic deficit in the central -nervous system .

HY-10351A

Robalzotan hydrochloride NAD-299 hydrochloride	5-HT Receptor	Neurological Disease
Robalzotan hydrochloride (NAD-299 hydrochloride) is a potent and selective **5-Hydroxytryptamine 1A (5-HT1A)** inhibitor. Robalzotan hydrochloride increases the firing rate of 5-HT cells. Robalzotan hydrochloride induces 5-HT1A receptor occupancy. Robalzotan hydrochloride has the potential for the research of a cholinergic deficit in the central -nervous system .

HY-12390

Lofepramine Lopramine	5-HT Receptor Adrenergic Receptor	Neurological Disease
Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and **5-hydroxytryptamine (5-HT) with IC₅₀s** of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. .

HY-12390A

Lofepramine hydrochloride Lopramine hydrochloride	5-HT Receptor Adrenergic Receptor	Neurological Disease
Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and **5-hydroxytryptamine (5-HT) with IC₅₀s** of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. .

HY-164083

GR65630	5-HT Receptor	Neurological Disease
GR65630 is a potent and selective 5-hydroxytryptamine (5-HT) type 3 receptor antagonist. GR65630 can be used to study the expression patterns of *5-HT3* receptors in different brain regions and their possible functions in the central nervous system. GR65630 and its radiolabeled form [ ³H]GR65630 can be used to study the distribution, density and affinity of the receptors .

HY-12390R

Lofepramine (Standard)	5-HT Receptor Adrenergic Receptor	Neurological Disease
Lofepramine (Standard) is the analytical standard of Lofepramine. This product is intended for research and analytical applications. Lofepramine (Lopramine) is a modified tricyclic and orally active antidepressant. Lofepramine inhibits the uptake of Noradrenaline (NA) (HY-13715) and 5-hydroxytryptamine (5-HT) with IC50s of 2.7 μM and 11 μM, respectively. Lofepramine exerts its antidepressant activity by promoting noradrenergic neurotransmission. Lofepramine also enhances serotonergic neurotransmission by inhibiting neuronal uptake of 5-HT and tryptophan pyrrolase. Lofepramine exhibits significant anxiolytic properties. .

HY-111200

Vabicaserin hydrochloride 3 Publications Verification SCA 136	5-HT Receptor	Neurological Disease
Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT_2C) receptor-selective agonist with an EC₅₀ of 8 nM.

HY-129101

(-)-Eseroline fumarate Eseroline fumarate	5-HT Receptor	Neurological Disease
(-)-Eseroline fumarate is a metabolic of Physostigmine (HY-N6608), an AChE inhibitor. (-)-Eseroline fumarate elicits a leakage of lactic acid dehydrogenase (LDH) from cancer cells. (-)-Eseroline fumarate also induces the release of adenine nucleotides and 5-hydroxytryptamine (5-HT) from neuronal cells, thus induce cell death. (-)-Eseroline fumarate inhibits the electrically evoked twitches of the mouse vas deferens and of the guinea-pig ileum .

HY-14431A

Cerlapirdine hydrochloride SAM-531 hydrochloride; PF-05212365 hydrochloride	5-HT Receptor	Neurological Disease
Cerlapirdine hydrochloride is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine hydrochloride has the potential for researching the Alzheimer's disease .

HY-19889

JNJ-18038683	5-HT Receptor	Neurological Disease
JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT₇) receptor antagonist, with pK_is of 8.19, 8.20 for rat and human 5-HT₇ in HEK293 cells, respectively.

HY-A0019A

Paliperidone palmitate 9-Hydroxyrisperidone palmitate	Dopamine Receptor 5-HT Receptor	Neurological Disease
Paliperidone palmitate is an orally effective competitive antagonist of dopamine D2 receptors and 5-hydroxytryptamine 2A (5-HT2A) receptors that can cross the blood-brain barrier. Paliperidone palmitate competitively inhibits the effects of dopamine and 5-hydroxytryptamine by binding to dopamine D2 receptors and 5-HT2A receptors, regulating the balance of the neurotransmitter system and thus exerting antipsychotic activity. Paliperidone palmitate is mainly used in the research field of schizophrenia .

HY-19889A

JNJ-18038683 free base	5-HT Receptor	Neurological Disease
JNJ-18038683 free base is a 5-Hydroxytryptamine Type 7 (5-HT₇) receptor antagonist, with pK_is of 8.19, 8.20 for rat and human 5-HT₇ in HEK293 cells, respectively.

HY-15472A

PRX-08066 maleate	5-HT Receptor	Cardiovascular Disease
PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that causes selective vasodilation of pulmonary arteries.

HY-15472

PRX-08066	5-HT Receptor	Cardiovascular Disease
PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that causes selective vasodilation of pulmonary arteries.

HY-169825

(S)-PF-04995274	5-HT Receptor Drug Isomer	Neurological Disease
(S)-PF-04995274 is a partial agonist of the 5-hydroxytryptamine receptor 4 (5-HT₄R) and is an isomer of PF-04995274 (HY-18137) .

HY-14431

Cerlapirdine 1 Publications Verification SAM-531; PF-05212365	5-HT Receptor	Neurological Disease
Cerlapirdine (SAM-531, PF-05212365) is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine has the potential for researching the Alzheimer's disease .

HY-123630

Allura Red AC FD&C RED NO. 40; CI 16035	5-HT Receptor TNF Receptor IFNAR Reactive Oxygen Species (ROS) Interleukin Related	Inflammation/Immunology
Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety .

HY-A0019AR

Paliperidone palmitate (Standard)	Dopamine Receptor 5-HT Receptor	Neurological Disease
Paliperidone palmitate (Standard) is the analytical standard of Paliperidone palmitate. This product is intended for research and analytical applications. Paliperidone palmitate is an orally effective competitive antagonist of dopamine D2 receptors and 5-hydroxytryptamine 2A (5-HT2A) receptors that can cross the blood-brain barrier. Paliperidone palmitate competitively inhibits the effects of dopamine and 5-hydroxytryptamine by binding to dopamine D2 receptors and 5-HT2A receptors, regulating the balance of the neurotransmitter system and thus exerting antipsychotic activity. Paliperidone palmitate is mainly used in the research field of schizophrenia .

HY-167639

(S)-Ramosetron (S)-YM060 free base	5-HT Receptor	Metabolic Disease
(S)-Ramosetron ((S)-YM060 free base) is an orally active antagonist of the 5-hydroxytryptamine 5-HT₃ receptor. (S)-Ramosetron is promising for research of diseases related to nausea and vomiting, irritable bowel syndrome (IBS) .

HY-15414A

Vortioxetine hydrobromide 5+ Cited Publications Lu AA21004 hydrobromide	5-HT Receptor Serotonin Transporter	Neurological Disease Cancer
Vortioxetine (Lu AA 21004) hydrobromide is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

HY-A0019AS

Paliperidone palmitate-d4 9-Hydroxyrisperidone palmitate-d₄	Isotope-Labeled Compounds Dopamine Receptor 5-HT Receptor	Neurological Disease
Paliperidone palmitate-d₄ (9-Hydroxyrisperidone palmitate-d₄) is the deuterium labeled Paliperidone palmitate (HY-A0019A). Paliperidone palmitate is an orally effective competitive antagonist of dopamine D2 receptors and 5-hydroxytryptamine 2A (5-HT2A) receptors that can cross the blood-brain barrier. Paliperidone palmitate competitively inhibits the effects of dopamine and 5-hydroxytryptamine by binding to dopamine D2 receptors and 5-HT2A receptors, regulating the balance of the neurotransmitter system and thus exerting antipsychotic activity. Paliperidone palmitate is mainly used in the research field of schizophrenia .

HY-14441

ML 10302	5-HT Receptor	Neurological Disease
ML 10302 is a potent agonist *5-HT4* receptor with K_i of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases .

HY-15414AR

Vortioxetine hydrobromide (Standard)	5-HT Receptor Serotonin Transporter	Neurological Disease Cancer
Vortioxetine (hydrobromide) (Standard) is the analytical standard of Vortioxetine (hydrobromide). This product is intended for research and analytical applications. Vortioxetine (Lu AA 21004) hydrobromide is an antagonist of 5-HT3A and 5-HT7 receptors (Ki: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (Ki: 1.6 nM), as well as a 5-HT1A agonist and a partial 5-HT1B agonist (Ki: 15 nM, 33 nM) .

HY-15414S

Vortioxetine-d8 Lu AA 21004 d₈	Isotope-Labeled Compounds 5-HT Receptor Serotonin Transporter	Neurological Disease
Vortioxetine-d₈ (Lu AA 21004-d₈) is a deuterated version of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

HY-15414AS

Vortioxetine-d8 hydrobromide Lu AA21004-d₈ hydrobromide	Isotope-Labeled Compounds 5-HT Receptor Serotonin Transporter	Neurological Disease
Vortioxetine-d₈ (Lu AA 21004-d₈) hydrobromide is the deuterated form of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

HY-123630R

Allura Red AC (Standard)	Fluorescent Dye Interleukin Related 5-HT Receptor IFNAR Reactive Oxygen Species (ROS)	Inflammation/Immunology
Allura Red AC (Standard) is an analytical standard of Allura Red AC. This product is intended for research and analytical applications. Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety .

HY-121562

SB 714786	5-HT Receptor	Neurological Disease
SB 714786 is a potent and selective 5-hydroxytryptamine 1D (5-HT1D) receptor antagonist. It was developed from the previously reported series of dual 5-HT1 selective 5-hydroxytryptamine reuptake inhibitors (5HT1-SSRIs). SB 714786 is the first reported highly potent and selective 5-HT1D receptor antagonist, providing an extremely useful pharmacological tool for further understanding the role of 5-HT1 receptor subtypes. It has no or very low intrinsic activity against all three receptors. SB 714786 has pKi values of 6.5, 6.7, 9.1 and 6.5 for 5-HT1A, 5-HT1B, 5-HT1D and SerT receptors, respectively, showing high selectivity for 5-HT1D receptors. These properties make SB 714786 a potential tool compound for studying the function of 5-HT1D receptors and the treatment of related diseases.

HY-15401A

WAY 163909 hydrochloride	5-HT Receptor	Others
WAY-163909 hydrochloride is a potent 5-hydroxytryptamine receptor 2C (5-HT2C) agonist with an EC50 of 8 nM and a maximum efficacy of 90%, while displaying minimal activity at 5-HT2A receptors. Its selectivity is further demonstrated by Ki values of 10.5 nM for 5-HT2C, alongside higher Ki values for 5-HT2A (212 nM), 5-HT7 (343 nM), and 5-HT2B (485 nM), and it lacks significant activity at various other receptors.

HY-10349A

WAY-100635 maleate 5+ Cited Publications	5-HT Receptor Dopamine Receptor	Neurological Disease
WAY-100635 maleate is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC₅₀ value of 0.91 nM and K_i value of 0.39 nM. WAY-100635 maleate has pIC₅₀ values for *5-HT1A* and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent dopamine D₄ receptor agonist .

HY-19927A

DA-6886 monohydrochloride	5-HT Receptor	Neurological Disease Endocrinology
DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist. DA-6886 induces relaxation of the rat oesophagus preparation in a *5-HT4* receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels reveals that it inhibits hERG channel current with an pIC₅₀ value of 4.3, indicating that the compound is 1000-fold more selective for the *5-HT4* receptor over hERG channels. DA-6886 can be used in the study of constipated irritable bowel syndrome .

HY-148032

5-Benzyloxytryptamine 5-BT	5-HT Receptor	Neurological Disease
5-Benzyloxytryptamine (5-BT) is a selective partial agonist for 5-hydroxytryptamine 1D/1B (5-HT₁D/₁B) receptors with an IC₅₀ value of 40 nM for bovine caudate 5-HT₁D and reduced affinity for other receptors (5-HT₂ IC₅₀>470 nM). 5-Benzyloxytryptamine inhibits adenylate cyclase to decrease neurotransmitter release and downregulate cAMP signaling. 5-Benzyloxytryptamine is promising for research of neurotransmitter imbalance-related disorders like migraine .

HY-10349

WAY-100635 5+ Cited Publications	5-HT Receptor Dopamine Receptor	Neurological Disease
WAY-100635 is a potent and selective 5-HT_1A Receptor antagonist with a pIC₅₀ of 8.87, an apparent pA₂ of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC₅₀ value of 0.91 nM and K_i value of 0.39 nM. WAY-100635 has pIC₅₀ values for *5-HT1A* and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent dopamine D₄ receptor agonist .

HY-10349AR

WAY-100635 maleate (Standard)	Reference Standards 5-HT Receptor Dopamine Receptor	Neurological Disease
WAY-100635 (maleate) (Standard) is the analytical standard of WAY-100635 (maleate). This product is intended for research and analytical applications. WAY-100635 maleate is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent dopamine D4 receptor agonist .

HY-10349R

WAY-100635 (Standard)	Reference Standards 5-HT Receptor Dopamine Receptor	Neurological Disease
WAY-100635 (Standard) is the analytical standard of WAY-100635. This product is intended for research and analytical applications. WAY-100635 is a potent and selective 5-HT1A Receptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent dopamine D4 receptor agonist .

HY-N1957

Gamma-Mangostin 2 Publications Verification γ-Mangostin	5-HT Receptor COX Transthyretin (TTR)	Metabolic Disease Inflammation/Immunology Cancer
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3 ^H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes ^[5].

HY-103116

DV-7028 hydrochloride	5-HT Receptor	Cardiovascular Disease
DV-7028 is a selective 5-hydroxytryptamine₂ (5-HT₂) receptor antagonist .

Cat. No.	Product Name	Type

HY-123630

Allura Red AC

FD&C RED NO. 40; CI 16035

Dyes

Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety .

HY-123630R

Allura Red AC (Standard)

Dyes

Allura Red AC (Standard) is an analytical standard of Allura Red AC. This product is intended for research and analytical applications. Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety .

Cat. No.	Product Name	Type

HY-59302

Indole-5-carboxylic acid, 98%	Cell Assay Reagents
Indole-5-carboxylic acid, 98% is an oxytocin that interacts with serotonin receptors and gamma-aminobutyric acid (GABA) receptors. It has also been reported to interact with various enzymes such as cyclooxygenase-2 (COX-2) and 5-hydroxytryptamine (5-HT) receptors.

HY-15401A

WAY 163909 hydrochloride

Biochemical Assay Reagents

WAY-163909 hydrochloride is a potent 5-hydroxytryptamine receptor 2C (5-HT2C) agonist with an EC50 of 8 nM and a maximum efficacy of 90%, while displaying minimal activity at 5-HT2A receptors. Its selectivity is further demonstrated by Ki values of 10.5 nM for 5-HT2C, alongside higher Ki values for 5-HT2A (212 nM), 5-HT7 (343 nM), and 5-HT2B (485 nM), and it lacks significant activity at various other receptors.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1473

Serotonin hydrochloride Maximum Cited Publications 15 Publications Verification 5-Hydroxytryptamine hydrochloride; 5-HT hydrochloride	Alkaloids Structural Classification Source classification Endogenous metabolite Indole Alkaloids	5-HT Receptor COMT Endogenous Metabolite
Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM.

HY-B1473A

Serotonin Maximum Cited Publications 15 Publications Verification 5-Hydroxytryptamine; 5-HT	Alkaloids Structural Classification Endogenous metabolite Indole Alkaloids	5-HT Receptor COMT Endogenous Metabolite
Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM.

HY-N0122

5-Hydroxytryptophan 1 Publications Verification 5-HTP; DL-5-Hydroxytryptophan	Structural Classification Monophenols Classification of Application Fields Source classification Disease markers Phenols Endocrine diseases Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite 5-HT Receptor
5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .

HY-N1957

Gamma-Mangostin 2 Publications Verification γ-Mangostin	Structural Classification Xanthones Classification of Application Fields Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Metabolic Disease Plants Disease Research Fields	5-HT Receptor COX Transthyretin (TTR)
Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3 ^H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes ^[5].

HY-N0122R

5-Hydroxytryptophan (Standard)	Structural Classification Monophenols Source classification Disease markers Phenols Endocrine diseases Amino acids Endogenous metabolite	Endogenous Metabolite 5-HT Receptor
5-Hydroxytryptophan (Standard) is the analytical standard of 5-Hydroxytryptophan. This product is intended for research and analytical applications. 5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .

HY-N1957R

Gamma-Mangostin (Standard) γ-Mangostin (Standard)	Structural Classification Xanthones Guttiferae Phenols Polyphenols Garcinia mangostana Linn. Plants	Reference Standards 5-HT Receptor COX Transthyretin (TTR)
Gamma-Mangostin (Standard) is the analytical standard of Gamma-Mangostin. This product is intended for research and analytical applications. Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer . Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC₅₀=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC₅₀=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes ^[5].

Cat. No.	Product Name	Chemical Structure

HY-B1473S

Serotonin-d4 hydrochloride
Serotonin-d₄ (5-Hydroxytryptamine-d₄) hydrochloride is the deuterium labeled Serotonin (hydrochloride) (HY-B1473) . Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

HY-15414AS

Vortioxetine-d8 hydrobromide
Vortioxetine-d₈ (Lu AA 21004-d₈) hydrobromide is the deuterated form of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

HY-B1473AS

Serotonin-d4
Serotonin-d₄ is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

HY-B1473S2

Serotonin-13C,D4
Serotonin- ¹³C,D₄ (5-Hydroxytryptamine-13C,D₄) is a ¹³C- and deuterated labeled Serotonin (HY-B1473A). Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

HY-A0019AS

Paliperidone palmitate-d4

Paliperidone palmitate-d₄ (9-Hydroxyrisperidone palmitate-d₄) is the deuterium labeled Paliperidone palmitate (HY-A0019A). Paliperidone palmitate is an orally effective competitive antagonist of dopamine D2 receptors and 5-hydroxytryptamine 2A (5-HT2A) receptors that can cross the blood-brain barrier. Paliperidone palmitate competitively inhibits the effects of dopamine and 5-hydroxytryptamine by binding to dopamine D2 receptors and 5-HT2A receptors, regulating the balance of the neurotransmitter system and thus exerting antipsychotic activity. Paliperidone palmitate is mainly used in the research field of schizophrenia .

HY-15414S

Vortioxetine-d8
Vortioxetine-d₈ (Lu AA 21004-d₈) is a deuterated version of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

HY-B1473S1

Serotonin-13C2,15N hydrochloride
Serotonin- ¹³C₂, ¹⁵N hydrochloride is the ¹³C- and ¹⁵N-labeled Serotonin hydrochloride (HY-B1473). Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83619

	HTR2C Antibody (YA3364) 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HTR2C; 5HT1C; 5HT2C; 5HTR2C; 5Hydroxytryptamine 2C receptor; HTr1c; HTR2C	WB	Human, Mouse, Rat
	HTR2C Antibody (YA3364) is a non-conjugated IgG antibody, targeting HTR2C, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). HTR2C Antibody (YA3364) can be used for WB experiment in human, mouse, rat background.

HY-P86758

	5-HT (Serotonin) Antibody (YA6451) 5 hydroxytryptamine antibody; 5HT antibody	WB, IHC-P, IF-Tissue, IHC-F, ELISA	Species independent

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