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Results for "

12-HETE

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Biochemical Assay Reagents (1) COX (1) Lipoxygenase (1) Prostaglandin Receptor (1)
By Research Areas:	Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (3) Metabolic Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: URAT1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113439

*12-HETE* 1 Publications Verification	Apoptosis	Cardiovascular Disease Inflammation/Immunology
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway ^[1].12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

HY-113439S

12-HETE-d8	Apoptosis	Cardiovascular Disease Inflammation/Immunology
12-HETE-d₈ is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway ^[1].12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

HY-119671

BW 755C	COX Lipoxygenase	Endocrinology
BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC₅₀ of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC₅₀s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively .

HY-CE00676

12-HETE-CoA 12-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
12-HETE-CoA (12-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.

HY-125122

Mulberrofuran A	Others	Inflammation/Immunology
Mulberrofuran A is a natural product, that can be isolated from the root bark of mulberry tree. Mulberrofuran A inhibits the formations of 12-hydroxy-,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products), but it increases the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (12-lipoxygenase product) .

HY-117044A

(±)12-HEPE	Prostaglandin Receptor	Metabolic Disease
(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC₅₀ values of 24 and 25 μM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC₅₀s=8.6-8.8 μM).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113439

*12-HETE* 1 Publications Verification	Microorganisms Source classification	Apoptosis
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway ^[1].12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

HY-125122

Mulberrofuran A	Monophenols Source classification Phenols Morus alba L. Plants Moraceae	Others
Mulberrofuran A is a natural product, that can be isolated from the root bark of mulberry tree. Mulberrofuran A inhibits the formations of 12-hydroxy-,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products), but it increases the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (12-lipoxygenase product) .

Cat. No.	Product Name	Chemical Structure

HY-113439S

12-HETE-d8
12-HETE-d₈ is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway ^[1].12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

12-HETE-d8

12-HETE-d₈ is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway ^[1].12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

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