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TP-020 (MGAT2-IN-1) is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.
mGAT3/4-IN-1 (compound 19b) is a potent mGAT3/mGAT4 inhibitor, with pIC50 values of 5.31 and 5.24, respectively. mGAT3/4-IN-1 exhibits a significant tactile allodynia reduction in diabetic neuropathic mice .
MGAT2-IN-4 (compound 33) is an inhibitor of monoacylglycerol transferase 2 (MGAT2), with liver metabolic stability. MGAT2-IN-4 can be used for research on obesity, diabetes and non-alcoholic steatohepatitis (NASH) .
MGAT2-IN-5 (Compound 17b) is a selective inhibitor for mouse GABA transit protection subsidity 2(mGAT2) with an IC50 of 45 μM. MGAT2-IN-5 exhibits anticonvulsive efficacy in audiogenic seizure (AGS) susceptible frings mouse model with an ED50 of 20.4 mg/kg .
mGAT-IN-1 (compound 28) is a potent and non-selective GAT inhibitor. mGAT-IN-1 has a high inhibitory potency toward mGAT3, with an IC50 of 2.5 μM and pIC50 of 5.61 .
Mgat1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mgat1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT5 Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mgat1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mgat5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mgat3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mgat2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT3 Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT4B Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT4B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT5B Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT5B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT4C Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT4C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mgat3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mgat2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT4A Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT4A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT2 Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mgat5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
N-Acetylglucosaminyltransferase V (MGAT4B) is the enzyme that catalyzes the formation of the β1,6-GlcNAc branch of N-glycans in the Golgi apparatus using UDP-GlcNAc as the donor substrate. N-Acetylglucosaminyltransferase V is involved in cancer malignancy and autoimmune disease etiology .
N-Acetylglucosaminyltransferase IVa (MGAT4A) is a glycosyltransferase that can enhance the migration, invasion, and adhesion abilities of cancer cells, and increase β1,4GlcNAc branched glycans on integrin β1 (ITGB1), a tumor-associated glycoprotein closely related to cell motility .
N-Acetylglucosaminyltransferase1 (EC:2.4.1.101, MGAT1) shows typical features of a type II transmembrane protein. N-Acetylglucosaminyltransferase1 is believed to be essential for normal embryogenesis .
TMEM68 Human Pre-designed siRNA Set A contains three designed siRNAs for TMEM68 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MOGAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for MOGAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MOGAT2 Human Pre-designed siRNA Set A contains three designed siRNAs for MOGAT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
POMGNT1 Human Pre-designed siRNA Set A contains three designed siRNAs for POMGNT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
BuChE-IN-9 (compound 22a) is a potent equine serum-derived BuChE (eqBuChE) inhibitor with an IC50 of 173 nM. BuChE-IN-9 also inhibits human BACE1, Aβ aggregation, mouse GABA transporter 1 (mGAT1) and mGAT4. BuChE-IN-9 has significant antiamnesic properties .
T863 is an orally active, selective and potent DGAT1 (acyl-CoA:diacylglycerol acyltransferase 1) inhibitor with an IC50 of 15 nM. T863 has no inhibitory activity against human MGAT3, human DGAT2, or human MGAT2. T863 interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells .
PST3.1a is a N-acetylglucosamine glycosyltransferase (MGAT5) inhibitor with the IC50 of 2 μM. PST3.1a inhibits glioblastoma-initiating cell invasiveness and proliferation .
JTP-103237 is a MGAT2 inhibitor (IC50: 0.019 μM and 6.423 μM for hMGAT2 and hMGAT3 respectively). JTP-103237 modulates fat absorption, decreases plasma glucose levels and prevents diet-induced obesity .
NNC 05-2090 hydrochloride is a GABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50< /sub>: 10.6 μM). NNC 05-2090 hydrochloride also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases .
NNC 05-2090 is aGABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50 sub>: 10.6 μM). NNC 05-2090 also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases .
LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively .
BMS-986172 is an orally active, highly selective MGAT2 inhibitor with an IC50 of 4.6 nM and 20 nM for hMGAT2 and mMGAT2, respectively. BMS-986172 has a T1/2>120 min in vitro assays. BMS-986172 reduces food intake and body weight. BMS-986172 has the potential for metabolic disorders such as obesity and NASH research .
N-Acetylglucosaminyltransferase III (EC:2.4.1.144 MGAT3) transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc .
N-Acetylglucosaminyltransferase1 (EC:2.4.1.101, MGAT1) shows typical features of a type II transmembrane protein. N-Acetylglucosaminyltransferase1 is believed to be essential for normal embryogenesis .
The MGAT5 protein regulates the cytoskeleton, adhesion, migration, and signaling. MGAT5 Protein, Human (HEK293, His) is the recombinant human-derived MGAT5 protein, expressed by HEK293 , with C-His labeled tag.
The MGAT2 protein plays an important role in protein N-glycosylation, catalyzing the transfer of GlcNAc to the free terminal mannose in nascent N-linked glycan chains. This forms a second branch of the complex glycan and is critical for glycoprotein maturation and functional diversity. MGAT2 Protein, Human (HEK293, His) is the recombinant human-derived MGAT2 protein, expressed by HEK293 , with C-6*His labeled tag.
The POMGNT1 protein crucially directs O-mannosyl glycosylation, which adds N-acetylglucosamine to O-linked mannose residues on glycoproteins. It catalyzes GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr on α-dystroglycan and other O-mannosylated proteins, laying the foundation for subsequent carbohydrate addition. POMGNT1 Protein, Human (HEK293, His) is the recombinant human-derived POMGNT1 protein, expressed by HEK293 , with C-6*His labeled tag.
Mgat1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mgat1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT5 Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mgat1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mgat5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mgat3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mgat2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT3 Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT4B Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT4B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT5B Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT5B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT4C Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT4C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mgat3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mgat2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT4A Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT4A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MGAT2 Human Pre-designed siRNA Set A contains three designed siRNAs for MGAT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Mgat5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mgat5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
TMEM68 Human Pre-designed siRNA Set A contains three designed siRNAs for TMEM68 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MOGAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for MOGAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
MOGAT2 Human Pre-designed siRNA Set A contains three designed siRNAs for MOGAT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
POMGNT1 Human Pre-designed siRNA Set A contains three designed siRNAs for POMGNT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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