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Results for "

CRM

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CRM1 (17) Antibiotic (3) Apoptosis (4) Autophagy (1) Bacterial (2) c-Myc (1) Cannabinoid Receptor (1) COX (1) Drug Metabolite (1) Fungal (1) HIV (2) Isotope-Labeled Compounds (1) Parasite (2) Reference Standards (2) RSV (1) Survivin (1)
By Research Areas:	Cancer (18) Infection (7) Inflammation/Immunology (1) Metabolic Disease (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: CRM1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108716

Felezonexor CBS9106; SL-801	CRM1 Apoptosis	Cancer
CBS9106 (SL-801) is a reversible oral *CRM1* inhibitor with CRM1 degrading and antitumor activities. CBS9106, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells .

HY-17539

KPT-276	CRM1	Cancer
PKT-276, an analogue of PKT-185, is an oral bioavailable and selective inhibitor of nuclear output (SINE). PKT-276 is also a *CRM1* antagonist that irreversibly binds to and blocks the function of CRM1 .

HY-155972A

CRM1-IN-2	CRM1 Apoptosis	Cancer
CRM1-IN-2 (Compound KL2) is a noncovalent *CRM1* inhibitor. CRM1-IN-2 localizes CRM1 in the nuclear periphery, depletes nuclear CRM1, and inhibits CRM1-mediated nuclear export. CRM1-IN-2 inhibits growth of colorectal cancer cells, and induces apoptosis .

HY-155972

CRM1-IN-1	CRM1	Cancer
CRM1-IN-1 (Compound KL1) is a noncovalent *CRM1* inhibitor. CRM1-IN-1 induces nuclear CRM1 degradation (IC₅₀: 0.27 μM). CRM1-IN-1 inhibits CRM1-mediated nuclear export and cell proliferation, and triggers apoptosis in colorectal cancer cells .

HY-157412

CRM1-IN-3	CRM1	Cancer
CRM1-IN-3 (B28) is a noncovalent CRM1 inhibitor. CRM1-IN-3 can be used for the research of protein localization and tumor .

HY-146384

CRM1 degrader 1	CRM1	Cancer
CRM1 degrader 1 (1l) is a low toxic chromosome region maintenance 1 (CRM1) degrader. CRM1 is the sole nuclear exporter of several tumor suppressor, a growth regulatory protein as an attractive cancer agent target. CRM1 degrader 1 induces the apoptosis in gastric carcinoma and selectively inhibits proliferation of gastric cancer .

HY-158747

*CBDPA (CRM)* Cannabidiphorolic acid	Drug Metabolite	Others
CBDPA (CRM) is a precursor to CBDP, a synthetic plant cannabinoid. CBDPA (CRM) is a standard substance .

HY-170014S

*2-Hydroxyethylflurazepam-d4 (CRM)*	Isotope-Labeled Compounds	Others
2-Hydroxyethylflurazepam-d₄ (CRM) is deuterium labeled 2-Hydroxyethylflurazepam (CRM) .

HY-114597

PKF050-638	HIV CRM1	Cancer
PKF050-638 is a potent and selective inhibitor of HIV-1 Rev (IC₅₀=0.04 μM). PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting *CRM1-NES* interaction .

HY-174219

BT-33	Bacterial	Infection
BT-33 is a fuorinated macrobicyclic oxepanoprolinamide antibiotic with broad-spectrum activity against multidrug-resistant bacterial pathogens .

HY-16909

Leptomycin B Maximum Cited Publications 9 Publications Verification CI 940; LMB	CRM1 Fungal Antibiotic	Infection Cancer
Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle .

HY-160296

AN-988	CRM1	Cancer
AN-988 (compund 6) is a covalent *CRM1* inhibitor .

HY-N6795

Leptomycin A	CRM1 HIV Antibiotic	Infection
Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B .

HY-116661

Cannabigerovarin CBGV	Cannabinoid Receptor	Metabolic Disease
Cannabigerovarin (CRM) (Item No. 29117) is a certified reference material categorized as a phytocannabinoid.1 This product is intended for research and forensic applications.

HY-17536

Selinexor 4 Publications Verification KPT-330	CRM1	Cancer
Selinexor (KPT-330), analog of KPT-185, is an orally bioavailable and selective *CRM1* inhibitor .

HY-15970

Verdinexor 2 Publications Verification KPT-335	CRM1 Apoptosis RSV	Infection Inflammation/Immunology Cancer
Verdinexor (KPT-335) is an orally active inhibitor for selective inhibitor of nuclear export (SINE). Verdinexor inhibits the respiratory syncytial virus A2 (RSV A2) replication with an IC₅₀ of 0.96 µM. Verdinexor inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1), inhibiting pro-inflammatory responses. Verdinexor exhibits antitumor effciency .

HY-17536A

(E)-Selinexor (E)-KPT-330	CRM1	Cancer
(E)-Selinexor ((E)-KPT-330) is the E-isomer of Selinexor (HY-17536). Selinexor is the selective, orally active *CRM1* inhibitor .

HY-117996

KPT-251	CRM1 Apoptosis	Cancer
KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity .

HY-17536R

Selinexor (Standard) KPT-330 (Standard)	Reference Standards CRM1	Cancer
Selinexor (Standard) is the analytical standard of Selinexor. This product is intended for research and analytical applications. Selinexor (KPT-330), analog of KPT-185, is an orally bioavailable and selective *CRM1* inhibitor .

HY-157136

LFS-1107	CRM1 COX c-Myc Survivin	Cancer
LFS-1107 is a reversible *CRM1* inhibitor (K_d: 12.5 pM). LFS-1107 can selectively eliminate extranodal natural killer/T cell lymphoma (ENKTL) cells and can be used for cancer research .

HY-W083373A

3,4-Dimethoxychalcone	Bacterial Autophagy	Cancer
3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research .

HY-118896

Acequinocyl AKD-2023; DPX-3792	Parasite	Infection
Acequinocyl (CRM) is a certified reference material categorized as a naphthoquinone acaricide.1 Acequinocyl has been found in Cannabis. Formulations containing acequinocyl have been used to control mite populations in agriculture. This product is intended for research and forensic applications.

HY-15611

KPT-185	CRM1	Cancer
KPT-185 is an orally bioavailable and selective inhibitor of *CRM1* and displays potent antiproliferative properties at submicromolar concentrations (IC₅₀=100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts .

HY-118896R

Acequinocyl (Standard) AKD-2023 (Standard); DPX-3792 (Standard)	Parasite Reference Standards	Infection
Acequinocyl (Standard) is the analytical standard of Acequinocyl. This product is intended for research and analytical applications. Acequinocyl (CRM) is a certified reference material categorized as a naphthoquinone acaricide.1 Acequinocyl has been found in Cannabis. Formulations containing acequinocyl have been used to control mite populations in agriculture. This product is intended for research and forensic applications.

HY-N10264

Avrainvillamide (+)-Avrainvillamide; CJ-17,665	Antibiotic	Infection Cancer
Avrainvillamide ((+)-Avrainvillamide) is a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Avrainvillamide affects cell biology both by directly binding NPM1 and Crm1 as well as by inhibiting the association of these proteins with certain native cellular partners. Avrainvillamide, an antibiotic, inhibits growth of multi-agent resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 μg/ml, respectively .

Cat. No.	Product Name

HY-L011

Membrane Transporter/Ion Channel Compound Library	1,822 compounds
Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development. MCE designs a unique collection of 1,822 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Membrane Transporter/Ion Channel Compound Library

1,822 compounds

Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development.

MCE designs a unique collection of 1,822 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6795

Leptomycin A	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	CRM1 HIV Antibiotic
Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B .

HY-N10264

Avrainvillamide (+)-Avrainvillamide; CJ-17,665	Infection Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Indole Alkaloids	Antibiotic
Avrainvillamide ((+)-Avrainvillamide) is a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Avrainvillamide affects cell biology both by directly binding NPM1 and Crm1 as well as by inhibiting the association of these proteins with certain native cellular partners. Avrainvillamide, an antibiotic, inhibits growth of multi-agent resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 μg/ml, respectively .

Cat. No.	Product Name	Chemical Structure

HY-170014S

*2-Hydroxyethylflurazepam-d4 (CRM)*
2-Hydroxyethylflurazepam-d₄ (CRM) is deuterium labeled 2-Hydroxyethylflurazepam (CRM) .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81809

	CRM1 Antibody (YA1554) XPO1; CRM1; Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	CRM1 Antibody (YA1554) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1554), targeting CRM1, with a predicted molecular weight of 123 kDa (observed band size: 110 kDa). CRM1 Antibody (YA1554) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

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