β-gal

By Targets:	Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (1) Endogenous Metabolite (2) Epigenetic Reader Domain (1) Fluorescent Dye (6) Glycosidase (4) NF-κB (1) PROTACs (1) TGF-beta/Smad (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (2) Metabolic Disease (3)

Targets Recommended: Galactokinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70298

*ST3 β-Gal* α-2,3-Sialyltransferase 1** ST3gal1	Endogenous Metabolite	Cancer
ST3 β-Gal α-2,3-Sialyltransferase 1 (ST3GAL1) is a sialyltransferase whose overexpression in ovarian cancer cell lines enhances cell growth, migration, and invasion capabilities, as well as increases tumorigenicity and resistance to paclitaxel in vivo. ST3 β-Gal α-2,3-Sialyltransferase 1 catalyzes the transfer of sialic acid from cytidine monophosphate-sialic acid to galactose-containing substrates and can be utilized in studies of cancer progression and chemotherapy resistance .

HY-D1879

*SPiDER-βGal-2*	Glycosidase Fluorescent Dye	Metabolic Disease
SPiDER-βGal-2 is a fluorogenic β-galactosidase substrate and suitable for labeling live cells in culture and in living tissues. SPiDER-βGal-2 can generate quinone methide through enzymatic reaction and form covalent bonds with nucleophilic functional groups of proteins near the molecule, so that the fluorescent product is fixed in living cells (Ex/Em = 493, 525 nm/560 nm) .

HY-D1878

*SPiDER-βGal-1*	Glycosidase Fluorescent Dye	Metabolic Disease
SPiDER-βGal-1 is a fluorogenic β-galactosidase substrate and suitable for labeling live cells in culture and in living tissues. SPiDER-βGal-1 can generate quinone methide through enzymatic reaction and form covalent bonds with nucleophilic functional groups of proteins near the molecule, so that the fluorescent product is fixed in living cells (Ex/Em = 493, 525 nm/560 nm) .

HY-W127769

Rose-β-D-Gal Salmon-gal	Fluorescent Dye	Others
Rose-β-D-Gal is a chromogenic substrate, is also a β-galactosidase substrate. Rose-β-D-Gal creates a pink/magenta color after the reaction and has been used for detection of β-gal activity .

HY-130570

β-Gal-NONOate	Bacterial	Infection Inflammation/Immunology
Beta-gal-nonoate is a β-galactosidase dependent nitric oxide (NO) donor that releases NO once activated by β-galactosidase. β-Gal-NONOate has bactericidal activity and can be used as a bactericide .

HY-E70299

*ST3 β-Gal* α-2,3-Sialyltransferase 5** ST3gal5	TGF-beta/Smad	Cancer
ST3 β-Gal α-2,3-Sialyltransferase 5 (ST3GAL5) is a glycosphingolipid (GSL) biosynthetic enzyme that can inhibit TGF-β-induced epithelial-mesenchymal transition (EMT), invasion, and metastasis both in vivo and in vitro. ST3 β-Gal α-2,3-Sialyltransferase 5 can be used in cancer research .

HY-N9134

5-O-Methylgenistein Isoprunetin	Glycosidase	Others
5-O-Methylgenistein (Isoprunetin) is an isoflavone that can be isolated from M. amurensis wood. 5-O-Methylgenistein inhibits *β-gal* activityy induced by 17β-Estradiol (HY-B0141) in yeast .

HY-151890

*NIR-βgal-2*	Fluorescent Dye	Cancer
NIR-βgal-2 is a β-galactosidase-activated near-infrared fluorescent probe with superior sensitivity. NIR-βgal-2 can be used for visualizing β-galactosidase in breast cancer .

HY-132239

5-Bromo-6-chloro-3-indolyl β-D-Galactopyranoside contains ca. 10% Ethyl Acetate 5-Bromo-6-chloro-3-indolyl-beta-D-galactoside	Biochemical Assay Reagents	Others
5-Bromo-6-chloro-3-indolyl β-D-Galactopyranoside (contains ca. 10% Ethyl Acetate) (5-Bromo-6-chloro-3-indolyl-beta-D-galactoside) is a chromogenic substrate of β-galactosidase (β-gal) .

HY-124445

APC0576	NF-κB	Inflammation/Immunology
APC0576 is an inhibitor for the activation of NF-κB signaling pathway, and inhibits the activation of NF-κB depedent gene (IC₅₀ is 1.0 μM for β-gal). APC0576 inhibits IL-1-induced chemokines release, and can be used in research about pathological endothelial cell activation releted diseases .

HY-165424

NIR-BG2	Fluorescent Dye Glycosidase	Cardiovascular Disease Cancer
NIR-BG2 is a near-infrared fluorescent probe targeting senescence-associated β-galactosidase (SA-β-Gal). NIR-BG2 is activated by SA-β-Gal and undergoes hydrolysis to release electrophilic quinone methide that covalently binds to surrounding proteins for in situ labeling, with a 16-fold enhancement of fluorescence signal at 709 nm . NIR-BG2 is promising for research of vivo imaging of cellular senescence .

HY-158331

Gal-ARV-771	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
Gal-ARV-771, PROTAC prodrug, is a gal modified ARV-771 (HY-100972). Gal-ARV-771 can be activated in SA-β-Gal-expressed cancer senescent cells to release ARV-771. Gal-ARV-771 induces selective degradation of BRD4 protein by the ubiquitin-proteasome pathway in senescent cells. Gal-ARV-771 promotes apoptosis of senescent cancer cells .

HY-E70053

alpha-1,3-Galactosyltransferase (GTB) alpha 1,3GT	Endogenous Metabolite	Metabolic Disease
alpha-1,3-Galactosyltransferase (GTB) (alpha 1,3GT) catalyzes the synthesis of the xenoantigen or α-galactose (α-Gal) epitope. alpha-1,3-Galactosyltransferase (GTB) transfers galactose from UDP-Gal to type 1 or type 2, αFuc1→2βGal-R (H)-terminating acceptors .

HY-158742

SBB-Analogue (GL13) Biotin 1 Publications Verification GL13; SBB-A-B	Fluorescent Dye	Others
SBB-Analogue (GL13) Biotin (GL13; SBB-A-B) is composed of a Sudan Black B (SBB; HY-D0213) derivative conjugated to biotin. SBB-Analogue (GL13) Biotin detects robustly senescent cells. SBB-Analogue (GL13) Biotin is deprived of the false positive staining disadvantages of SA-β-gal due to serum starvation and cell confluency. SBB-Analogue (GL13) Biotin can be used in flow cytometry and immunofluorescence analysis, etc .

Cat. No.	Product Name	Type

HY-D1879

*SPiDER-βGal-2*	Fluorescent Dyes/Probes
SPiDER-βGal-2 is a fluorogenic β-galactosidase substrate and suitable for labeling live cells in culture and in living tissues. SPiDER-βGal-2 can generate quinone methide through enzymatic reaction and form covalent bonds with nucleophilic functional groups of proteins near the molecule, so that the fluorescent product is fixed in living cells (Ex/Em = 493, 525 nm/560 nm) .

HY-D1878

*SPiDER-βGal-1*	Fluorescent Dyes/Probes
SPiDER-βGal-1 is a fluorogenic β-galactosidase substrate and suitable for labeling live cells in culture and in living tissues. SPiDER-βGal-1 can generate quinone methide through enzymatic reaction and form covalent bonds with nucleophilic functional groups of proteins near the molecule, so that the fluorescent product is fixed in living cells (Ex/Em = 493, 525 nm/560 nm) .

HY-W127769

Rose-β-D-Gal Salmon-gal	Fluorescent Dyes/Probes
Rose-β-D-Gal is a chromogenic substrate, is also a β-galactosidase substrate. Rose-β-D-Gal creates a pink/magenta color after the reaction and has been used for detection of β-gal activity .

HY-151890

*NIR-βgal-2*	Fluorescent Dyes/Probes
NIR-βgal-2 is a β-galactosidase-activated near-infrared fluorescent probe with superior sensitivity. NIR-βgal-2 can be used for visualizing β-galactosidase in breast cancer .

Cat. No.	Product Name	Type

HY-E70146

*ST3 β-Gal* α-2,3-Sialyltransferase 2** EC:2.4.3.4; ST3gal2	Enzyme Substrates
ST3 beta-Gal alpha-2,3-Sialyltransferase 2 (EC:2.4.3.4, ST3GAL2) catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates .

HY-E70147

*ST3 β-Gal* α-2,3-Sialyltransferase 6** EC:2.4.99.; ST3gal6; Type 2 lactosamine α-2,3-sialyltransferase	Enzyme Substrates
ST3 beta-Gal alpha-2,3-Sialyltransferase 6 (EC:2.4.99., ST3GAL6; SIAT10, Type 2 lactosamine alpha-2,3-sialyltransferase) transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. ST3 beta-Gal alpha-2,3-Sialyltransferase 6 play an important role in cancer .

ST3 β-Gal α-2,3-Sialyltransferase 6

EC:2.4.99.; ST3gal6; Type 2 lactosamine α-2,3-sialyltransferase

Enzyme Substrates

ST3 beta-Gal alpha-2,3-Sialyltransferase 6 (EC:2.4.99., ST3GAL6; SIAT10, Type 2 lactosamine alpha-2,3-sialyltransferase) transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. ST3 beta-Gal alpha-2,3-Sialyltransferase 6 play an important role in cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9134

5-O-Methylgenistein Isoprunetin	Flavonoids Leguminosae Source classification Maackia amurensis Rupr. et Maxim. Plants Isoflavones	Glycosidase
5-O-Methylgenistein (Isoprunetin) is an isoflavone that can be isolated from M. amurensis wood. 5-O-Methylgenistein inhibits *β-gal* activityy induced by 17β-Estradiol (HY-B0141) in yeast .

HY-165424

NIR-BG2	Alkaloids Other Alkaloids Cananga odorata Source classification Plants Annonaceae Indole Alkaloids	Fluorescent Dye Glycosidase
NIR-BG2 is a near-infrared fluorescent probe targeting senescence-associated β-galactosidase (SA-β-Gal). NIR-BG2 is activated by SA-β-Gal and undergoes hydrolysis to release electrophilic quinone methide that covalently binds to surrounding proteins for in situ labeling, with a 16-fold enhancement of fluorescence signal at 709 nm . NIR-BG2 is promising for research of vivo imaging of cellular senescence .

Species:	Human (1) E.coli (1)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P7859

	Beta-galactosidase/GLB1 Protein, E.coli rEcoBeta-galactosidase; Beta-galactosidase; Beta-gal; Lactase; lacZ	E.coli	E. coli
	Beta-galactosidase/GLB1 protein is a hydrolase with catalytic activity and binding sites of Mg²⁺, Mn²⁺ and Na⁺. Beta-galactosidase/GLB1 protein can be used for research in genetics, molecular biology, and other life sciences. Beta-galactosidase/GLB1 Protein, E.coli is the recombinant E. coli-derived Beta-galactosidase/GLB1 protein, expressed by E. coli , with tag free.

HY-P705434

	B3GNT5 Protein, Human (His) Lactotriaosylceramide synthase; Lc3; Lc3 synthase; UDP-GlcNAc:beta-gal beta-1,3-N-acetylglucosaminyltransferase 5; BGnT-5; Beta-1,3-Gn-T5; Beta-1,3-N-acetylglucosaminyltransferase 5; Beta3Gn-T5	Human	E. coli

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