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Brcc3

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  • HY-P72107
    BRCC36 Protein, Human (His-SUMO)

    BRCA1-A complex subunit Brcc36; BRCA1/BRCA2 containing complex subunit 3; BRCA1/BRCA2 containing complex subunit 36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; Brcc3; Brcc3_HUMAN; Brcc36; BRISC complex subunit Brcc36; C6.1A ; Chromosome X open reading frame 53; CXorf53; Lys-63-specific deubiquitinase Brcc36; OTTHUMP00000061450

    		 Human E. coli
    BRCC36 is a metalloprotease that selectively cleaves "Lys-63" linked polyubiquitin chains, especially histones H2A and H2AX in the BRCA1-A complex during the DNA damage response. As the catalytic subunit of the BRISC complex, it also targets “Lys-63”-linked ubiquitin in various substrates, affecting mitotic spindle assembly and interferon signaling. BRCC36 Protein, Human (His-SUMO) is the recombinant human-derived BRCC36 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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