2. GPCR/G Protein Apoptosis
  3. Protease Activated Receptor (PAR) Apoptosis
  4. SCH79797 dihydrochloride (Standard)

SCH79797 dihydrochloride (Standard) 

Cat. No.: HY-14994R Purity: ≥98%
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SCH79797 (dihydrochloride) (Standard) is the analytical standard of SCH79797 (dihydrochloride). This product is intended for research and analytical applications. SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes.

For research use only. We do not sell to patients.

SCH79797 dihydrochloride (Standard) Chemical Structure

SCH79797 dihydrochloride (Standard) Chemical Structure

CAS No. : 1216720-69-2

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Description

SCH79797 (dihydrochloride) (Standard) is the analytical standard of SCH79797 (dihydrochloride). This product is intended for research and analytical applications. SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes.

Molecular Weight

444.40

Formula

C23H27Cl2N5
CAS No.
SMILES

Cl[H].Cl[H].NC1=NC(NC2CC2)=NC3=CC=C(N(CC4=CC=C(C(C)C)C=C4)C=C5)C5=C31
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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SCH79797 dihydrochloride (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH79797 dihydrochloride (Standard)1216720-69-2Protease Activated Receptor (PAR)ApoptosisThrombin receptorsNonpeptidethrombinplateletsPAR1cardioprotectionthrombosiswortmannininfarctantiproliferativepro-apoptoticInhibitorinhibitorinhibit

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