2. Metabolic Enzyme/Protease
  3. MMP
  4. RS-104966

RS-104966 is a potent collagenase-1 (MMP-1) inhibitor. RS-104966 induces a conformational change in the side chains of the S10 pocket of MMP-1.

For research use only. We do not sell to patients.

RS-104966

RS-104966 Chemical Structure

CAS No. : 193022-38-7

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RS-104966 Related Antibodies

Top Publications Citing Use of Products

View All MMP Isoform Specific Products:

View All Isoforms
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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Description

RS-104966 is a potent collagenase-1 (MMP-1) inhibitor. RS-104966 induces a conformational change in the side chains of the S10 pocket of MMP-1[1].

IC50 & Target[1]

collagenases 1

 

Molecular Weight

391.44

Formula

C19H21NO6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NO)CC1(S(=O)(C2=CC=C(OC3=CC=CC=C3)C=C2)=O)CCOCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (255.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5547 mL 12.7733 mL 25.5467 mL
5 mM 0.5109 mL 2.5547 mL 5.1093 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5547 mL 12.7733 mL 25.5467 mL 63.8667 mL
5 mM 0.5109 mL 2.5547 mL 5.1093 mL 12.7733 mL
10 mM 0.2555 mL 1.2773 mL 2.5547 mL 6.3867 mL
15 mM 0.1703 mL 0.8516 mL 1.7031 mL 4.2578 mL
20 mM 0.1277 mL 0.6387 mL 1.2773 mL 3.1933 mL
25 mM 0.1022 mL 0.5109 mL 1.0219 mL 2.5547 mL
30 mM 0.0852 mL 0.4258 mL 0.8516 mL 2.1289 mL
40 mM 0.0639 mL 0.3193 mL 0.6387 mL 1.5967 mL
50 mM 0.0511 mL 0.2555 mL 0.5109 mL 1.2773 mL
60 mM 0.0426 mL 0.2129 mL 0.4258 mL 1.0644 mL
80 mM 0.0319 mL 0.1597 mL 0.3193 mL 0.7983 mL
100 mM 0.0255 mL 0.1277 mL 0.2555 mL 0.6387 mL
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RS-104966 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS-104966193022-38-7RS104966RS 104966MMPMatrix metalloproteinasesS10 pocketcollagenase-1Inhibitorinhibitorinhibit

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