2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Immunology/Inflammation
  3. ROR Interleukin Related
  4. RORγt inverse agonist 35

RORγt inverse agonist 35 (Compound 22) is a RORγt inverse agonist with an IC50 of 1.51 μM. RORγt inverse agonist 35 significantly inhibits Th17 differentiation and proinflammatory properties in human CD4+ T cells. RORγt inverse agonist 35 can be used for research of Th17-driven autoimmune diseases, such as psoriasis, multiple sclerosis, and inflammatory bowel disease (IBD).

For research use only. We do not sell to patients.

RORγt inverse agonist 35 Chemical Structure

RORγt inverse agonist 35 Chemical Structure

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RORγt inverse agonist 35 Related Antibodies

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Description

RORγt inverse agonist 35 (Compound 22) is a RORγt inverse agonist with an IC50 of 1.51 μM. RORγt inverse agonist 35 significantly inhibits Th17 differentiation and proinflammatory properties in human CD4+ T cells. RORγt inverse agonist 35 can be used for research of Th17-driven autoimmune diseases, such as psoriasis, multiple sclerosis, and inflammatory bowel disease (IBD)[1].

IC50 & Target

RORγt

1.51 μM (IC50)

IL-17A

 

IL-17F

 

IL-22

 

IL-21

 

Molecular Weight

450.53

Formula

C25H23FN2O3S
SMILES

CC(S(=O)(C1=CC=C(C=C1)C2=CN3C=C(C=C3C=C2)C(NCC4=CC=C(C=C4)F)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RORγt inverse agonist 35 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RORγt inverse agonist 35RORγt inverse agonist35RORγt inverse agonist-35RORInterleukin RelatedRAR-related orphan receptorILRORγTInverse agonistJurkat cellsCD4+ T cellsAutoimmune diseasesPsoriasisMultiple sclerosisIBDInhibitorinhibitorinhibit

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