2. Immunology/Inflammation
  3. Complement System
  4. Refinicopan

Refinicopan is a complement factor D inhibitor with an IC50 of 10 nM. Refinicopan inhibits rabbit erythrocyte hemolysis with an IC50 of 41 nM. Refinicopan exhibits excellent pharmacokinetic and pharmacodynamic activity.

For research use only. We do not sell to patients.

Refinicopan Chemical Structure

Refinicopan Chemical Structure

CAS No. : 2922808-66-8

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Description

Refinicopan is a complement factor D inhibitor with an IC50 of 10 nM. Refinicopan inhibits rabbit erythrocyte hemolysis with an IC50 of 41 nM. Refinicopan exhibits excellent pharmacokinetic and pharmacodynamic activity[1].

IC50 & Target

Complement factor D

10 nM (IC50)

Molecular Weight

456.58

Formula

C29H32N2O3
CAS No.
SMILES

NCC1=CC=CC(C2=CC(N3CCC4(CC3)CC4)=CC(COC5=C(C=CC=C5)CC(O)=O)=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Refinicopan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Refinicopan2922808-66-8Complement SystemInhibitorinhibitorinhibit

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