2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS)
  4. Redaporfin

Redaporfin  (Synonyms: LUZ11; F2BMet)

Cat. No.: HY-17644 Purity: 99.44%
COA
SDS
Handling Instructions Technical Support

Redaporfin (LUZ11) acts as a potent photosensitizer. Redaporfin causes direct antineoplastic effects as well as indirect immune-dependent destruction of malignant lesions.

For research use only. We do not sell to patients.

Redaporfin

Redaporfin Chemical Structure

CAS No. : 1224104-08-8

Size Price Stock
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO Ask For Quote & Lead Time
Solid
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Redaporfin Related Antibodies

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Description

Redaporfin (LUZ11) acts as a potent photosensitizer. Redaporfin causes direct antineoplastic effects as well as indirect immune-dependent destruction of malignant lesions[1].

In Vitro

The combination photodynamic therapy (PDT) with Redaporfin (5μM) induces a reduction in the abundance of several Golgi apparatus (GA) proteins such as Golgi brefeldin A-resistant guanine nucleotide exchange factor 1 (GBF1), golgin subfamily A member 2 (GOLGA2), and galactosyltransferase 1 (GALT1), as well as that of two ER proteins, eukaryotic translation initiation factor 2-alpha (eIF2α) kinase 3 (EIF2AK3) and protein disulfide-isomerase A3 (PDIA3). In contrast, there is no major decrease in mitochondrial import receptor subunit TOM20 homolog (TOMM20) or in the cytoskeleton protein β-actin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Redaporfin Related Antibodies

Western Blot Analysis[1]

Cell Line: Human osteosarcoma U2OS cells
Concentration: 0.3, 0.6, 1.3, 2.5, 5, 10 μM
Incubation Time: 6 hours
Result: Induced a reduction in the abundance of GBF1, GOLGA2, and GALT1, as well as EIF2AK3 and PDIA3.
Clinical Trial
Molecular Weight

1135.11

Formula

C48H38F8N8O8S4
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

O=S(C1=CC=C(F)C(/C2=C3CCC(/C(C4=C(F)C(S(=O)(NC)=O)=CC=C4F)=C5C=C/C(N/5)=C(C6=C(F)C(S(=O)(NC)=O)=CC=C6F)/C(CC/7)=NC7=C(C8=C(F)C(S(=O)(NC)=O)=CC=C8F)/C9=CC=C2N9)=N\3)=C1F)(NC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (88.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8810 mL 4.4049 mL 8.8097 mL
5 mM 0.1762 mL 0.8810 mL 1.7619 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.44%

SDS (252 KB)

COA (266 KB) HNMR (328 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8810 mL 4.4049 mL 8.8097 mL 22.0243 mL
5 mM 0.1762 mL 0.8810 mL 1.7619 mL 4.4049 mL
10 mM 0.0881 mL 0.4405 mL 0.8810 mL 2.2024 mL
15 mM 0.0587 mL 0.2937 mL 0.5873 mL 1.4683 mL
20 mM 0.0440 mL 0.2202 mL 0.4405 mL 1.1012 mL
25 mM 0.0352 mL 0.1762 mL 0.3524 mL 0.8810 mL
30 mM 0.0294 mL 0.1468 mL 0.2937 mL 0.7341 mL
40 mM 0.0220 mL 0.1101 mL 0.2202 mL 0.5506 mL
50 mM 0.0176 mL 0.0881 mL 0.1762 mL 0.4405 mL
60 mM 0.0147 mL 0.0734 mL 0.1468 mL 0.3671 mL
80 mM 0.0110 mL 0.0551 mL 0.1101 mL 0.2753 mL
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Redaporfin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Redaporfin1224104-08-8LUZ11 F2BMetLUZ 11LUZ-11Reactive Oxygen Species (ROS)PhotodynamictherapyendoplasmicreticulumGolgiInhibitorinhibitorinhibit

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