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  4. TPO/Thrombopoietin Protein, Cynomolgus (353a.a, HEK293, His)

TPO/Thrombopoietin Protein, Cynomolgus (353a.a, HEK293, His)

Cat. No.: HY-P703861
Handling Instructions Technical Support

TPO/Thrombopoietin Protein, Cynomolgus (353a.a, HEK293, His) is the recombinant cynomolgus-derived TPO/Thrombopoietin protein, expressed by HEK293, with C-His tag.

For research use only. We do not sell to patients.

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Description

TPO/Thrombopoietin Protein, Cynomolgus (353a.a, HEK293, His) is the recombinant cynomolgus-derived TPO/Thrombopoietin protein, expressed by HEK293, with C-His tag.
Background

Thrombopoietin (TPO), a lineage-specific cytokine, exerts a pivotal influence on the proliferation and maturation of megakaryocytes, particularly at the late stages of their development from committed progenitor cells. Notably, TPO emerges as a potential major physiological regulator in the intricate orchestration of circulating platelets, underscoring its crucial role in megakaryocyte biology and platelet formation.
Species

Cynomolgus
Source

HEK293
Tag

C-His
Accession

XP_005546625.1 (M1-G353)
Gene ID

102144240
Protein Length

Full Length
Synonyms
thrombopoietin
Predicted Molecular Mass
36.8 kDa
Molecular Weight

Approximately 70-80 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Purity

Greater than 85% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

TPO/Thrombopoietin Protein, Cynomolgus (353a.a, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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