MMP-8 Protein, Human (Active, 242a.a, HEK293, His)

MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Human (Active, 242a.a, HEK293, His) is the recombinant human-derived MMP-8 protein, expressed by HEK293, with C-His labeled tag.

MMP-8, also referred to as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic capabilities and specifically its ability to break down fibrillar type I, II, and III collagens. This enzymatic activity suggests that MMP-8 plays a significant role in the remodeling and turnover of collagen-rich tissues, such as connective tissues, cartilage, and bone. By degrading these fibrillar collagens, MMP-8 can contribute to processes such as tissue remodeling, wound healing, and inflammation resolution. Understanding the precise functions and regulation of MMP-8 can provide valuable insights into its involvement in collagen metabolism and tissue remodeling, potentially offering therapeutic opportunities for conditions characterized by abnormal collagen degradation or accumulation.

Human

HEK293

C-His

P22894 (F21-G262)

4317

Approximately 38-55 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 90% as determined by reducing SDS-PAGE.

Solution.

Supplied as 0.22 μm filtered solution of 50 mM Tris,150 mM NaCl,pH8.0 with trehalose as protectant.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.