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CLEC12A/MICL Protein, Human (HEK293, Biotinylated, Avi, Fc)

Cat. No.: HY-P703892
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CLEC12A/MICL (C-type lectin domain family 12 member A/myelosuppressive C-type lectin-like receptor) is a cell surface receptor that acts as a modulator of signaling cascades, specifically promoting target MAP kinases Protease. CLEC12A/MICL Protein, Human (HEK293, Biotinylated, Avi, Fc) is the recombinant human-derived CLEC12A/MICL protein, expressed by HEK293, with N-Avi and N-hFc labeled tag.

For research use only. We do not sell to patients.

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Description

CLEC12A/MICL (C-type lectin domain family 12 member A/myelosuppressive C-type lectin-like receptor) is a cell surface receptor that acts as a modulator of signaling cascades, specifically promoting target MAP kinases Protease. CLEC12A/MICL Protein, Human (HEK293, Biotinylated, Avi, Fc) is the recombinant human-derived CLEC12A/MICL protein, expressed by HEK293, with N-Avi and N-hFc labeled tag.
Background

CLEC12A/MICL (C-type lectin domain family 12 member A/Myeloid inhibitory C-type lectin-like receptor) is a cell surface receptor that functions as a regulator of signaling cascades, specifically facilitating the tyrosine phosphorylation of target MAP kinases. Through its interactions with PTPN6 and PTPN11, CLEC12A/MICL is implicated in intricate cellular signaling processes, suggesting its significance in modulating immune responses and potentially serving as a target for therapeutic interventions aimed at manipulating immune system function.
Species

Human
Source

HEK293
Tag

N-Avi;hFc
Accession

Q5QGZ9-1 (H75-A275)
Gene ID

160364
Protein Length

Partial
Synonyms
MICL; CLL-1; CLEC12A; CLL1; DCAL2; DCAL-2; CD371; CD303; CLECSF11; CLECSF7; DLEC; HECL; PRO34150; DCAL-2
Predicted Molecular Mass
51.6 kDa
Molecular Weight

Approximately 68.81 kDa,based on SDS-PAGE under reducing conditions.
Glycosylation
Yes
Purity

Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CLEC12A/MICL Protein, Human (HEK293, Biotinylated, Avi, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CLEC12A/MICL Protein, Human (HEK293, Biotinylated, Avi, Fc)
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