CD2 Protein, Human (185a.a, Biotinylated, HEK293, His, Avi)

CD2 Protein, a cell surface glycoprotein, plays a crucial role in T-cell activation and adhesion. It interacts with its ligand, CD58, facilitating immune responses and cell-to-cell communication. CD2 Protein is also a potential target for immunotherapy and may contribute to the development of novel treatments for immune-related disorders. CD2 Protein, Human (185a.a, Biotinylated, HEK293, His, Avi) is the recombinant human-derived CD2 protein, expressed by HEK293, with C-Avi and C-His labeled tag.

The CD2 protein plays a pivotal role in mediating adhesion between T-cells and other cell types by interacting with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1. Beyond its adhesive function, CD2 is implicated in triggering T-cells, with its cytoplasmic domain serving a crucial role in signaling. CD2 also interacts with CD48 and CD58 (LFA-3), underscoring its involvement in cellular interactions. Additionally, CD2 engages with CD2AP and PSTPIP1, suggesting its versatility in cellular signaling pathways. Notably, the interaction between CD2 and FCGR3A modulates NK cell activation and cytotoxicity, highlighting the diverse roles of CD2 in immune cell functions.

Human

HEK293

C-Avi;C-8*His

P06729 (K25-D209)

914

Extracellular Domain

Approximately 35-45 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.