Prostaglandin H2  (Synonyms: PGH2)

Prostaglandin H2 (PGH2) is an endothelium-derived contracting factor. Prostaglandin H2 can cause vasoconstriction. Prostaglandin H2 is the common precursor of all PGs and is produced by several cells that express cyclooxygen-ases. Prostaglandin H2 can activate PGD2 receptors CRTH2 and DP via interacting directly with the receptors and/or by giving rise to PGD2 after catalytic conversion by plasma proteins. Prostaglandin H2 can induce eosinophils migration and inhibit platelet aggregation. Prostaglandin H2 can accelerate the formation of dimers and higher oligomers of amyloid β_1-42. Prostaglandin H2 can be used for the researches of inflammation and neurological disease, such as Alzheimer disease^[1][2][3].

Prostaglandin H2 (75 nM, 4 mins) increase in forward-scatter of eosinophils^[1].
Prostaglandin H2 (0-100 nM) induces shape changes and Ca²⁺ production in eosinophils^[1].
Prostaglandin H2 (0-100 nM) induces migration and collagen-induced platelet aggregation in eosinophils^[1].
Prostaglandin H2 (0-100 nM) inhibits eosinophil degranulation by activation of CRTH2 receptors^[1].
Prostaglandin H2 (45 μM, 3-24 h) accelerates the rate of formation of dimers and higher oligomers of amyloid β_1-42^[2].
Prostaglandin H2 (1-1000 nM) induces contraction of rabbit pulmonary artery, with an EC₅₀ of 500 nM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

352.47

C₂₀H₃₂O₅

42935-17-1

Liquid

Colorless to light yellow

CCCCC[C@H](O)/C=C/[C@@H]1[C@H]([C@]2([H])C[C@@]1([H])OO2)C/C=C\CCCC(O)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Schuligoi R, et al. Prostaglandin H2 induces the migration of human eosinophils through the chemoattractant receptor homologous molecule of Th2 cells, CRTH2. J Leukoc Biol. 2009 Jan;85(1):136-45.  [Content Brief]

  [2]. Boutaud O, et al. Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers. J Neurochem. 2002 Aug;82(4):1003-6.  [Content Brief]

  [3]. Saito M, et al. Endothelium-derived prostaglandin H2 evokes the stretch-induced contraction of rabbit pulmonary artery. Eur J Pharmacol. 2003 Apr 25;467(1-3):151-61.  [Content Brief]