2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Immunology/Inflammation
  3. PPAR COX
  4. PPARγ agonist 19

PPARγ agonist 19 (Compound 5e) is a PPARγ agonist. PPARγ agonist 19 has an IC50 of 11.27 μM against COX-1 and an IC50 of 0.05 μM against COX-1. PPARγ agonist 19 increases glucose uptake in rat hemidiaphragm assay and is superior to pioglitazone (HY-13956). PPARγ agonist 19 alleviates hyperglycemia and insulin resistance in an in vivo model of type 2 diabetes in rats and protects against renal and lipidemia damage caused by metabolic dysfunction.

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PPARγ agonist 19 Chemical Structure

PPARγ agonist 19 Chemical Structure

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PPARγ agonist 19 Related Antibodies

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Description

PPARγ agonist 19 (Compound 5e) is a PPARγ agonist. PPARγ agonist 19 has an IC50 of 11.27 μM against COX-1 and an IC50 of 0.05 μM against COX-1. PPARγ agonist 19 increases glucose uptake in rat hemidiaphragm assay and is superior to pioglitazone (HY-13956). PPARγ agonist 19 alleviates hyperglycemia and insulin resistance in an in vivo model of type 2 diabetes in rats and protects against renal and lipidemia damage caused by metabolic dysfunction[1].

IC50 & Target

PPARγ

 

COX-1

11.27 μM (IC50)

COX-2

0.05 μM (IC50)

Molecular Weight

503.57

Formula

C20H17N5O5S3
SMILES

O=S(C1=CC=C(N2N=NC(COC3=CC=C(/C=C(SC(N4)=S)/C4=O)C=C3OC)=C2)C=C1)(N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PPARγ agonist 19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPARγ agonist 19PPARγ agonist19PPARγ agonist-19PPARCOXPeroxisome proliferator-activated receptorsCyclooxygenaseInhibitorinhibitorinhibit

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