PLGA-PEG-PLGA (hydrogel) (LA:GA 3:1) 

PLGA-PEG-PLGA (hydrogel) (LA:GA 3:1) is a biodegradable thermosensitive hydrogel product that can undergo phase transition at a specific temperature. PLGA-PEG-PLGA (hydrogel) (LA:GA 3:1) can be widely used in drug delivery systems, tissue engineering, wound dressings, and biosensors^[1].

Gelation temperature: varies with concentration. The higher the concentration, the lower the gelation temperature. When the concentration is 15-20 wt%, the gelation temperature is between 31-34℃.
Gel preparation method:
(1) Remove the solid raw material from the frozen environment, return it to room temperature, remove the condensed water on the outer packaging, and then open it.
(2) Add phosphate buffer, complete culture medium or distilled water to the bottle according to the environment in which the gel is used, and prepare a 15-20% (w/w) solution.
(3) Stir at room temperature in a cool environment (≤25℃) for 24 hours. Hours, until the polymer is completely dissolved, and the thermosensitive hydrogel is obtained;
(4) The prepared thermosensitive hydrogel is fully cooled at 4℃, and then sterilized by filtration using a 0.22 μm polyethersulfone syringe filter under a sterile environment.
Note:
(1) Generally, the gelation temperature of the hydrogel prepared using isotonic solutions such as phosphate buffer and complete culture medium is about 1-2℃ lower than that of the hydrogel prepared using distilled water;
(2) After adding the solvent and during the dissolution process, scrape the gelled solid from the bottle wall, bottle cap, etc. with a spatula several times to allow it to fully contact the solvent, which can accelerate the dissolution of the polymer.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[PLGA-PEG-PLGA (hydrogel) (LA:GA 3:1)]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gao Y, et al. PLGA-PEG-PLGA hydrogel for ocular drug delivery of dexamethasone acetate. Drug Dev Ind Pharm. 2010 Oct;36(10):1131-8.  [Content Brief]