2. Others Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. Biochemical Assay Reagents EGFR
  4. PF-06672131

PF-06672131 is an alkynylated afatinib derivative and a small molecule probe that is reactive to cysteine. PF-06672131 is an inhibitor of epidermal growth factor receptor (EGFR) kinase that targets the ATP pockets of EGFR. PF-06672131 can be used for activity-based protein profiling studies.

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PF-06672131 Chemical Structure

PF-06672131 Chemical Structure

CAS No. : 1621002-27-4

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PF-06672131 Related Antibodies

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Description

PF-06672131 is an alkynylated afatinib derivative and a small molecule probe that is reactive to cysteine. PF-06672131 is an inhibitor of epidermal growth factor receptor (EGFR) kinase that targets the ATP pockets of EGFR. PF-06672131 can be used for activity-based protein profiling studies[1].

Molecular Weight

453.90

Formula

C23H21ClFN5O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC#C)/C=C/CN(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (275.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2031 mL 11.0156 mL 22.0313 mL
5 mM 0.4406 mL 2.2031 mL 4.4063 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2031 mL 11.0156 mL 22.0313 mL 55.0782 mL
5 mM 0.4406 mL 2.2031 mL 4.4063 mL 11.0156 mL
10 mM 0.2203 mL 1.1016 mL 2.2031 mL 5.5078 mL
15 mM 0.1469 mL 0.7344 mL 1.4688 mL 3.6719 mL
20 mM 0.1102 mL 0.5508 mL 1.1016 mL 2.7539 mL
25 mM 0.0881 mL 0.4406 mL 0.8813 mL 2.2031 mL
30 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8359 mL
40 mM 0.0551 mL 0.2754 mL 0.5508 mL 1.3770 mL
50 mM 0.0441 mL 0.2203 mL 0.4406 mL 1.1016 mL
60 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9180 mL
80 mM 0.0275 mL 0.1377 mL 0.2754 mL 0.6885 mL
100 mM 0.0220 mL 0.1102 mL 0.2203 mL 0.5508 mL
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PF-06672131 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-066721311621002-27-4PF06672131PF 06672131Biochemical Assay ReagentsEGFREpidermal growth factor receptorErbB-1HER1alkynylated afatinibInhibitorinhibitorinhibit

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