PERK/eIF2α activator 1

Cat. No.: HY-158196 Purity: 98.88%: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

PERK/eIF2α activator 1 (compound V8) is a flavonoid with an anti-tumor activity. PERK/eIF2α activator 1 induces apoptosis and activates the PERK-eIF2α-ATF4 pathway. PERK/eIF2α activator 1 inhibits HepG2 cell proliferation with an IC₅₀ value of 23 μM.

For research use only. We do not sell to patients.

PERK/eIF2α activator 1 Chemical Structure

CAS No. : 1178583-17-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.26 μM Compound: 3b	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28117202]
HepG2	IC₅₀	2.64 μM Compound: 3b	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28117202]

Molecular Weight

443.49

Formula

C₂₄H₂₉NO₇

CAS No.

1178583-17-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C=C(C2=CC=CC=C2)OC3=C(C(OCCCCN(CCO)CCO)=CC(O)=C13)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (225.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2548 mL	11.2742 mL	22.5484 mL
5 mM	0.4510 mL	2.2548 mL	4.5097 mL
10 mM	0.2255 mL	1.1274 mL	2.2548 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.88%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (245 KB) HNMR (257 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Yi Zhang, et al. V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. Arch Toxicol. 2014, 88, 1. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2548 mL	11.2742 mL	22.5484 mL	56.3711 mL
	5 mM	0.4510 mL	2.2548 mL	4.5097 mL	11.2742 mL
	10 mM	0.2255 mL	1.1274 mL	2.2548 mL	5.6371 mL
	15 mM	0.1503 mL	0.7516 mL	1.5032 mL	3.7581 mL
	20 mM	0.1127 mL	0.5637 mL	1.1274 mL	2.8186 mL
	25 mM	0.0902 mL	0.4510 mL	0.9019 mL	2.2548 mL
	30 mM	0.0752 mL	0.3758 mL	0.7516 mL	1.8790 mL
	40 mM	0.0564 mL	0.2819 mL	0.5637 mL	1.4093 mL
	50 mM	0.0451 mL	0.2255 mL	0.4510 mL	1.1274 mL
	60 mM	0.0376 mL	0.1879 mL	0.3758 mL	0.9395 mL
	80 mM	0.0282 mL	0.1409 mL	0.2819 mL	0.7046 mL
	100 mM	0.0225 mL	0.1127 mL	0.2255 mL	0.5637 mL