2. Metabolic Enzyme/Protease Apoptosis
  3. Phosphodiesterase (PDE) NAMPT Apoptosis
  4. PDEδ/NAMPT IN-1

PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) (KD=0.410 nM) and nicotinamide phosphoribosyl transferase (NAMPT) (IC50=2.21 nM). PDEδ/NAMPT IN-1 blocks KRAS-related signal transduction and interferes with the synthesis of nicotinamide adenine dinucleotide (NAD+), inducing apoptosis in KRAS mutant pancreatic cancer cells. PDEδ/NAMPT IN-1 is promising for research of KRAS mutant pancreatic cancer.

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PDEδ/NAMPT IN-1 Chemical Structure

PDEδ/NAMPT IN-1 Chemical Structure

CAS No. : 2976498-55-0

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PDEδ/NAMPT IN-1 Related Antibodies

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Description

PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) (KD=0.410 nM) and nicotinamide phosphoribosyl transferase (NAMPT) (IC50=2.21 nM). PDEδ/NAMPT IN-1 blocks KRAS-related signal transduction and interferes with the synthesis of nicotinamide adenine dinucleotide (NAD+), inducing apoptosis in KRAS mutant pancreatic cancer cells. PDEδ/NAMPT IN-1 is promising for research of KRAS mutant pancreatic cancer[1].

IC50 & Target

PDE6

0.41 nM (Kd)

Molecular Weight

494.61

Formula

C26H30N4O4S
CAS No.
SMILES

O=S(C1=CC=C(C=C1)NC(NCC2=CC=CN=C2)=O)(N(CC3=CC=C(C=C3)OC)C4CCCC4)=O
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Purity & Documentation
References
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PDEδ/NAMPT IN-1 Related Classifications

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Keywords:

PDEδ/NAMPT IN-12976498-55-0Phosphodiesterase (PDE)NAMPTApoptosisNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorPDE6KRAS mutant pancreatic cancerInhibitorinhibitorinhibit

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