2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. Pasireotide pamoate

Pasireotide pamoate  (Synonyms: SOM230 pamoate)

Cat. No.: HY-108768 Purity: 99.47%
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Pasireotide (SOM230) pamoate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide pamoate exhibits antisecretory, antiproliferative, and proapoptotic activity.

For research use only. We do not sell to patients.

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Pasireotide pamoate Chemical Structure

Pasireotide pamoate Chemical Structure

CAS No. : 396091-79-5

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Pasireotide pamoate:

Pasireotide pamoate Related Antibodies

Top Publications Citing Use of Products

    Pasireotide pamoate purchased from MedChemExpress. Usage Cited in: Am J Pathol. 2018 Apr;188(4):981-994.  [Abstract]

    Representative western blot and quantitation of band density show an increase expression of acetylated α-tubulin in PCK cholangiocytes upon ACY-1215 and ACY-1215+Pasireotide treatment.

    Pasireotide pamoate purchased from MedChemExpress. Usage Cited in: Hepatology. 2017 Oct;66(4):1197-1218.  [Abstract]

    Concurrent treatment of ADPKD cholangiocytes by SBI-115 and Pasireotide decreases cell proliferation, cholangiocyte spheroid growth, and cAMP levels.

    View All Somatostatin Receptor Isoform Specific Products:

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    SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

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    • Purity & Documentation

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    Description

    Pasireotide (SOM230) pamoate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide pamoate exhibits antisecretory, antiproliferative, and proapoptotic activity[1][2].

    IC50 & Target

    pKi: 8.2 (sst1), 9.0 (sst2), 9.1 (sst3), <7.0 (sst4), 9.9 (sst5)[1]
    In Vitro

    Pasireotide pamoate exhibits unique high-affinity binding to human somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively)[1].
    Pasireotide pamoate effectively inhibits the growth hormone releasing hormone (GHRH) induced growth hormone (GH) release in primary cultures of rat pituitary cells, with an IC50 of 0.4 nM[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Pasireotide pamoate Related Antibodies
    In Vivo

    Pasireotide pamoate (160 mg/kg/mouth; s.c. for 4 months) significantly decreases the serum insulin, increases serum glucose, reduces the tumor size and increases apoptosis in Pdx1-Cre[2].
    Pasireotide pamoate (2-50 μg/kg; s.c. twice daily for 42 days) exerts the antinociceptive and antiinflammatory actions via the SSTR2 receptor in a mouse model of immune-mediated arthritis[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 12 month-old conditional Men1 knockout mice with insulinoma[2]
    Dosage: 160 mg/kg/mouth
    Administration: S.c. every month for 4 months
    Result: Decreased the serum insulin from 1.060 μg/L to 0.3653 μg/L and increased the serum glucose from 4.246 mM to 7.122 mM.
    Significantly reduced the tumor size and increased apoptosis.
    Clinical Trial
    Molecular Weight

    1435.58

    Formula

    C81H82N10O15
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (69.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.6966 mL 3.4829 mL 6.9658 mL
    5 mM 0.1393 mL 0.6966 mL 1.3932 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.6966 mL 3.4829 mL 6.9658 mL 17.4146 mL
    5 mM 0.1393 mL 0.6966 mL 1.3932 mL 3.4829 mL
    10 mM 0.0697 mL 0.3483 mL 0.6966 mL 1.7415 mL
    15 mM 0.0464 mL 0.2322 mL 0.4644 mL 1.1610 mL
    20 mM 0.0348 mL 0.1741 mL 0.3483 mL 0.8707 mL
    25 mM 0.0279 mL 0.1393 mL 0.2786 mL 0.6966 mL
    30 mM 0.0232 mL 0.1161 mL 0.2322 mL 0.5805 mL
    40 mM 0.0174 mL 0.0871 mL 0.1741 mL 0.4354 mL
    50 mM 0.0139 mL 0.0697 mL 0.1393 mL 0.3483 mL
    60 mM 0.0116 mL 0.0580 mL 0.1161 mL 0.2902 mL
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    Pasireotide pamoate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Pasireotide396091-79-5SOM230SOM 230SOM-230Somatostatin ReceptorSSTRsSSTRsomatostatinsst1sst2sst3sst4sst5antisecretoryantiproliferativeproapoptoticInhibitorinhibitorinhibit

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