2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Paridiprubart

Paridiprubart  (Synonyms: NI-0101)

Cat. No.: HY-145645 Purity: ≥95.0%
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Paridiprubart (NI-0101) is a humanised anti-TLR4 monoclonal antibody. Paridiprubar inhibits the production of pro-inflammatory cytokines by monocytes from rheumatoid arthritis specimen induced by rheumatoid arthritis synovial fluid (RASF). Paridiprubart can be used for the study of rheumatoid arthritis.

For research use only. We do not sell to patients.

CAS No. : 2641646-59-3

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Based on 1 publication(s) in Google Scholar

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Description

Paridiprubart (NI-0101) is a humanised anti-TLR4 monoclonal antibody. Paridiprubar inhibits the production of pro-inflammatory cytokines by monocytes from rheumatoid arthritis specimen induced by rheumatoid arthritis synovial fluid (RASF). Paridiprubart can be used for the study of rheumatoid arthritis[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

TLR4[1]
In Vitro

Paridiprubar (20 μg/mL, pre-treated for 30 minutes) significantly inhibits the production of pro-inflammatory cytokines by monocytes from rheumatoid arthritis specimen induced by rheumatoid arthritis synovial fluid (RASF)[1].
Paridiprubar inhibits the production of TNF-α by macrophages stimulated by citrullinated fibrinogen immune complexes (cFb-IC) through an Fc-dependent mechanism[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Paridiprubart Related Antibodies

ELISA Assay[1]

Cell Line: Monocytes from rheumatoid arthritis specimen
Concentration: 20 μg/mL
Incubation Time: pre-treated for 30 minutes
Result: Reduced the production of pro-inflammatory cytokines such as IL-6, TNFα, IL-1β and IL-8.
Clinical Trial
Gene ID

7099  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.16 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Paridiprubart]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Flow cytometric analysis of 1X106 Jurkat cells with Paridiprubart (HY-145645, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Purity & Documentation
References
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Paridiprubart Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Paridiprubart2641646-59-3NI-0101NI0101NI 0101Toll-like Receptor (TLR)monoclonal antibodyrheumatoid arthritis synovial fluid (RASF)Inhibitorinhibitorinhibit

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