Paclitaxel poliglumex 

Paclitaxel poliglumex is a macromolecular Paclitaxel (HY-B0015) conjugate. Paclitaxel poliglumex is synthesized from the biodegradable polymer poly-L-glutamic acid and paclitaxel^[1]. Paclitaxel poliglumex can be used for cancer research, such as ovarian cancer and melanoma^[1][2].

Paclitaxel poliglumex (80 mg/kg, i.v., once daily for 5 days) being synergistic with Carboplatin (HY-17393), inhibits tumor growth in female C3Hf/KAM mice bearing OCa-I tumor cells^[1].
Paclitaxel poliglumex (40 mg/kg, i.v., single dose) has a long circulation time in plasma in female mice with subcutaneous B16 murine melanomas^[1].
Paclitaxel poliglumex (PG-TXL) (20 mg/kg, i.v., single dose) exhibits superior tumor accumulation capability in an Oca-1 tumor-bearing mouse model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1013.09

C₅₄H₆₄N₂O₁₇

263351-82-2

CC(O[C@]12[C@@]3([H])[C@@H]([C@]4(C(C)(C([C@H](C([C@@]3([C@H](C[C@@]1([H])OC2)O)C)=O)OC(C)=O)=C([C@H](C4)OC([C@H](O)[C@H](C5=CC=CC=C5)NC(C6=CC=CC=C6)=O)=O)C)C)O)OC(C7=CC=CC=C7)=O)=O.CC(CCC(C(O)=O)NC)=O.[n]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Singer JW, et al. Paclitaxel poliglumex (XYOTAX; CT-2103): an intracellularly targeted taxane. Anticancer Drugs. 2005 Mar;16(3):243-54.

  [2]. Li C, et al. Biodistribution of paclitaxel and poly(L-glutamic acid)-paclitaxel conjugate in mice with ovarian OCa-1 tumor. Cancer Chemother Pharmacol. 2000;46(5):416-22.