2. MAPK/ERK Pathway Cell Cycle/DNA Damage
  3. p38 MAPK MAPKAPK2 (MK2) CDK Wee1
  4. p38α inhibitor 9

p38α inhibitor 9 (Compound 2015) is a p38α inhibitor and blocks p38α’s enzymatic activity with an IC50 lower than 20 nM. p38α inhibitor 9 inhibits MK2T334 phosphorylation. p38α inhibitor 9 activates Cdc25b and Cdc25c and simultaneously inactivates Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy and DNA damage. p38α inhibitor 9 Inhibits colorectal cancer (CRC) metastasis.

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p38α inhibitor 9 Chemical Structure

p38α inhibitor 9 Chemical Structure

CAS No. : 2133007-20-0

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p38α inhibitor 9 Related Antibodies

Top Publications Citing Use of Products

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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Description

p38α inhibitor 9 (Compound 2015) is a p38α inhibitor and blocks p38α’s enzymatic activity with an IC50 lower than 20 nM. p38α inhibitor 9 inhibits MK2T334 phosphorylation. p38α inhibitor 9 activates Cdc25b and Cdc25c and simultaneously inactivates Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy and DNA damage. p38α inhibitor 9 Inhibits colorectal cancer (CRC) metastasis[1].

In Vivo

sp38α inhibitor 9 (20 mg/kg, p.o.) shows a high plasma concentration (Cmax = 20.7 µM) and a good stability in mice (t1/2 = 161 min)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

457.50

Formula

C27H24FN3O3
CAS No.
SMILES

CNC(C1=CC=C2C(C(C(C=CC(NC3=CC=C(F)C(NC(C4CC4)=O)=C3)=C5)=C5CC2)=O)=C1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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p38α inhibitor 9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p38α inhibitor 92133007-20-0p38 MAPKMAPKAPK2 (MK2)CDKWee1Mitogen-activated protein kinase activated protein kinase 2MAP kinase activated protein kinase 2MAPK activated protein kinase 2MAPKAP kinase 2Cyclin dependent kinaseCRCDNA damagecolorectal cancerInhibitorinhibitorinhibit

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